Sudden onset of confusion with severe exacerbation of parkinsonism during levodopa therapy

Mov Disord. 1986;1(4):267-70. doi: 10.1002/mds.870010406.

Abstract

Two patients with Parkinson's disease presented with unprovoked, abrupt onset of hallucinations, confusion and the simultaneous worsening of parkinsonian symptoms. This clinical syndrome appears to be a rare complication of dopaminergic therapy since improvement occurred gradually with reduction of Sinemet dosage.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carbidopa / administration & dosage
  • Carbidopa / adverse effects*
  • Cognition Disorders / chemically induced*
  • Confusion / chemically induced*
  • Dose-Response Relationship, Drug
  • Drug Combinations / administration & dosage
  • Drug Combinations / adverse effects
  • Humans
  • Levodopa / administration & dosage
  • Levodopa / adverse effects*
  • Male
  • Parkinson Disease, Secondary / chemically induced*

Substances

  • Drug Combinations
  • carbidopa, levodopa drug combination
  • Levodopa
  • Carbidopa