The gastric mucosa changes induced by enterogastric reflux remain to interest, thus, 20 patients with surgical duodenal ulcer disease were studied, and after raffle, they consisted in 2 groups of 10 patients each, in which were performed antrectomy and truncal vagotomy, with reestablishment of the gastrointestinal continuity, in the group I, through a Billroth II gastrojejunostomy, and, in the group II, by a Roux-en-Y gastrojejunostomy. In the preoperative course, all the patients were undergone to endoscopic and histopathologic studies, when body gastric mucosa biopsies were analysed; after an average time of follow-up about 7.3 months for the group I, and 8.9 months for the group II, these studies were repeated in an attempt to check, in these 2 groups, the presence of gastric mucosa changes on the gastric remnant induced by reflux of alkaline juices. According to Fisher's exact test the outcome of these searches were significants when had compared the bile reflux into the stomach (p = 0.0549), gastritis (p = 0.00) and anastomosis changes (p = 0.0899) at endoscopic study, and were not significants when it comes to the condition of chronic gastritis (p = 0.6672) present at histopathologic study.