Factoring in the force: A novel role for eIF6

Darren Graham Samuel Wilson; Thomas Iskratsch

doi:10.1083/jcb.202201002

Factoring in the force: A novel role for eIF6

J Cell Biol. 2022 Feb 7;221(2):e202201002. doi: 10.1083/jcb.202201002. Epub 2022 Jan 21.

Authors

Darren Graham Samuel Wilson^{1

2}, Thomas Iskratsch¹

Affiliations

¹ School of Engineering and Materials Science, Queen Mary University of London, London, UK.
² William Harvey Research Institute, Queen Mary University of London, London, UK.

Abstract

eIF6 is known for its role as a stimulatory translation initiation factor. In this issue, Keen et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202005213) identify a novel, noncanonical role, whereby eIF6 regulates focal adhesion formation, mechanosensing, and cell mechanics, independent of its translational role.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Peptide Initiation Factors*

Substances

Peptide Initiation Factors

Abstract

Publication types

MeSH terms

Substances

Grants and funding