Thermoregulation is a homeostatic mechanism that is disrupted in some neurological diseases. Patients with multiple sclerosis (MS) are susceptible to increases in body temperature, especially with more severe neurological signs. This condition can become intolerable when these patients suffer febrile infections such as coronavirus disease-2019 (COVID-19). We review the mechanisms of hyperthermia in patients with MS, and they may encounter when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Finally, the thermoregulatory role and relevant adaptation to regular physical exercise are summarized.
Keywords: ANS Autonomic nervous system; APN, Adiponectin; CNS, Central nervous system; COVID-19, Coronavirus disease-2019; EDHF, Endothelial-derived hyperpolarizing factor; MS, Multiple sclerosis; Multiple sclerosis; NLRP3, NLR family pyrin domain containing 3; NO, Nitric oxide; PACAP, Pituitary adenylate cyclase-activating polypeptide; PAMPs, Pathogen-associated molecular patterns; PGE(2), Prostaglandin E(2); PGs, Prostaglandins; ROS, Reactive oxygen species; SARS-CoV-2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SNS, Sympathetic nervous system; TRPV-1, Transient receptor potential vanilloid type 1; VDP, Vascular-dilating prostanoids; VEGF, Vascular endothelial growth factor; VIP, Vasoactive intestinal peptide; eNOS, Endothelial nitric oxide synthase; exercise; sweat gland; thermoregulation.
Copyright © 2022 Elsevier B.V. All rights reserved.