The aqueous humor proteome is intrinsically disordered

Mak Djulbegovic; Vladimir N Uversky

doi:10.1016/j.bbrep.2022.101202

The aqueous humor proteome is intrinsically disordered

Biochem Biophys Rep. 2022 Jan 28:29:101202. doi: 10.1016/j.bbrep.2022.101202. eCollection 2022 Mar.

Authors

Mak Djulbegovic¹, Vladimir N Uversky^{2

3}

Affiliations

¹ Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17St, Miami, FL, 33136, USA.
² Department of Molecular Medicine, Morsani College of Medicine, University of South, Florida, Bruce B. Downs Blvd., MDC07, Tampa, FL, 33612, USA.
³ Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy Pereulok, 9, Dolgoprudny, 141700, Moscow Region, Russia.

Abstract

•Our study demonstrated that intrinsic disorder is abundant in the aqueous humor.•The 749 aqueous proteins analyzed were enriched with disorder-promoting residues.•208 aqueous humor proteins were predicted to be highly intrinsically disordered.•Misregulation of IDPs may promote pathology in the aqueous humor.•IDPs in aqueous humor may serve as future targets for novel therapeutics.