Native valve infective endocarditis due to sequence type 97 community-associated methicillin-resistant Staphylococcus aureus complicated by meningitis and multiple septic emboli in a young healthy adult

Yuka Kawabe; Aki Sakurai; Toshiharu Sasaki; Makoto Hasegawa; Masahiro Suzuki; Naoki Hoshino; Chihiro Nakashima; Atsuo Maekawa; Yohei Doi

doi:10.1016/j.jiac.2022.01.020

Native valve infective endocarditis due to sequence type 97 community-associated methicillin-resistant Staphylococcus aureus complicated by meningitis and multiple septic emboli in a young healthy adult

J Infect Chemother. 2022 Jun;28(6):828-832. doi: 10.1016/j.jiac.2022.01.020. Epub 2022 Feb 11.

Authors

Yuka Kawabe¹, Aki Sakurai², Toshiharu Sasaki¹, Makoto Hasegawa¹, Masahiro Suzuki³, Naoki Hoshino⁴, Chihiro Nakashima⁴, Atsuo Maekawa⁵, Yohei Doi⁶

Affiliations

¹ Department of Infectious Diseases, Fujita Health University School of Medicine, Aichi, Japan.
² Department of Infectious Diseases, Fujita Health University School of Medicine, Aichi, Japan. Electronic address: [email protected].
³ Department of Microbiology, Fujita Health University School of Medicine, Aichi, Japan.
⁴ Department of Cardiology, Fujita Health University School of Medicine, Aichi, Japan.
⁵ Department of Cardiovascular Surgery, Fujita Health University School of Medicine, Aichi, Japan.
⁶ Department of Infectious Diseases, Fujita Health University School of Medicine, Aichi, Japan; Department of Microbiology, Fujita Health University School of Medicine, Aichi, Japan.

PMID: 35165010
DOI: 10.1016/j.jiac.2022.01.020

Abstract

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) can cause a wide variety of infections, ranging from skin and soft tissue infections to life-threatening invasive diseases such as necrotizing pneumonia and infective endocarditis. Here, we present a case of a healthy young female presenting with fever, headache and nausea, who was diagnosed with mitral valve infective endocarditis due to CA-MRSA and whose course was complicated by meningitis and multiple septic emboli. The causative MRSA strain belonged to sequence type 97 and harbored SCCmec Ⅳc but not lukS/F-PV genes. ST97, which is frequently isolated from livestock animals and known as a common lineage of livestock-associated MRSA, may cause invasive infection in the community.

Keywords: Community acquired infection; Infective endocarditis; Methicillin-resistant Staphylococcus aureus.

Publication types

Case Reports

MeSH terms

Animals
Community-Acquired Infections* / drug therapy
Endocarditis* / complications
Female
Humans
Meningitis*
Methicillin-Resistant Staphylococcus aureus* / genetics
Staphylococcal Infections* / complications
Staphylococcal Infections* / diagnosis
Staphylococcal Infections* / drug therapy