Objective: To review the research progress on the role of Schwann cells in regulating bone regeneration.
Methods: The domestic and foreign literature about the behavior of Schwann cells related to bone regeneration, multiple tissue repair ability, nutritional effects of their neurotrophic factor network, and their application in bone tissue engineering was extensively reviewed.
Results: As a critical part of the peripheral nervous system, Schwann cells regulate the expression level of various neurotrophic factors and growth factors through the paracrine effect, and participates in the tissue regeneration and differentiation process of non-neural tissues such as blood vessels and bone, reflecting the nutritional effect of neural-vascular-bone integration.
Conclusion: Taking full advantage of the multipotent differentiation ability of Schwann cells in nerve, blood vessel, and bone tissue regeneration may provide novel insights for clinical application of tissue engineered bone.
目的: 对雪旺细胞调控骨组织再生的研究进展进行综述。.
方法: 广泛查阅国内外雪旺细胞对组织再生研究的相关文献，从雪旺细胞的骨再生作用、多样化促进组织再生能力、旁分泌神经因子网络的营养效应和其在骨组织工程学中的应用等多个方面进行总结分析。.
结果: 作为周围神经系统的组成部分，雪旺细胞通过旁分泌效应，调控多种神经营养因子和生长因子的表达，从而有效参与到了血管和骨骼等非神经组织的再生分化过程，体现了其具有神经-血管-骨整合的营养效应。.
结论: 充分利用雪旺细胞的神经、血管和骨骼组织多能化再生效应，可为组织工程骨的临床应用提供新思路。.
Keywords: Schwann cells; bone tissue engineering; growth factor; neurotrophic factor; osteogenesis; vascularization.