Diagnosis, Prognosis and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors

Andrigo Barboza de Nardi; Rodrigo Dos Santos Horta; Carlos Eduardo Fonseca-Alves; Felipe Noleto de Paiva; Laís Calazans Menescal Linhares; Bruna Fernanda Firmo; Felipe Augusto Ruiz Sueiro; Krishna Duro de Oliveira; Silvia Vanessa Lourenço; Ricardo De Francisco Strefezzi; Carlos Henrique Maciel Brunner; Marcelo Monte Mor Rangel; Paulo Cesar Jark; Jorge Luiz Costa Castro; Rodrigo Ubukata; Karen Batschinski; Renata Afonso Sobral; Natália Oyafuso da Cruz; Adriana Tomoko Nishiya; Simone Crestoni Fernandes; Simone Carvalho Dos Santos Cunha; Daniel Guimarães Gerardi; Guilherme Sellera Godoy Challoub; Luiz Roberto Biondi; Renee Laufer-Amorim; Paulo Ricardo de Oliveira Paes; Gleidice Eunice Lavalle; Rafael Ricardo Huppes; Fabrizio Grandi; Carmen Helena de Carvalho Vasconcellos; Denner Santos Dos Anjos; Ângela Cristina Malheiros Luzo; Julia Maria Matera; Miluse Vozdova; Maria Lucia Zaidan Dagli

doi:10.3390/cells11040618

Diagnosis, Prognosis and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors

Cells. 2022 Feb 10;11(4):618. doi: 10.3390/cells11040618.

Authors

Andrigo Barboza de Nardi¹, Rodrigo Dos Santos Horta², Carlos Eduardo Fonseca-Alves^{3

4}, Felipe Noleto de Paiva¹, Laís Calazans Menescal Linhares¹, Bruna Fernanda Firmo⁵, Felipe Augusto Ruiz Sueiro⁶, Krishna Duro de Oliveira⁷, Silvia Vanessa Lourenço⁸, Ricardo De Francisco Strefezzi⁹, Carlos Henrique Maciel Brunner¹⁰, Marcelo Monte Mor Rangel¹¹, Paulo Cesar Jark¹², Jorge Luiz Costa Castro¹³, Rodrigo Ubukata¹⁴, Karen Batschinski¹⁴, Renata Afonso Sobral¹⁵, Natália Oyafuso da Cruz¹⁶, Adriana Tomoko Nishiya¹⁷, Simone Crestoni Fernandes¹⁸, Simone Carvalho Dos Santos Cunha¹⁹, Daniel Guimarães Gerardi²⁰, Guilherme Sellera Godoy Challoub²¹, Luiz Roberto Biondi²², Renee Laufer-Amorim²³, Paulo Ricardo de Oliveira Paes², Gleidice Eunice Lavalle²⁴, Rafael Ricardo Huppes²⁵, Fabrizio Grandi²⁶, Carmen Helena de Carvalho Vasconcellos²⁷, Denner Santos Dos Anjos^{1

28}, Ângela Cristina Malheiros Luzo²⁹, Julia Maria Matera³⁰, Miluse Vozdova³¹, Maria Lucia Zaidan Dagli³²

Affiliations

¹ Department of Veterinary Clinic and Surgery, Universidade Estadual Paulista (UNESP), Jaboticabal 14884-900, Brazil.
² Department of Veterinary Medicine and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
³ Institute of Health Sciences, Universidade Paulista (UNIP), Bauru 17048-290, Brazil.
⁴ Department of Veterinary Surgery and Animal Reproduction, Universidade Estadual Paulista (UNESP), Botucatu 18618-681, Brazil.
⁵ Department of Veterinary Medicine, Universidade Federal do Paraná, Curitiba 80035-050, Brazil.
⁶ Histopathological Diagnosis Department, VETPAT-Animal Pathology & Molecular Biology, Campinas 13073-022, Brazil.
⁷ Surgical Pathology, Vet Câncer LTDA-ME, São Paulo 04523-013, Brazil.
⁸ General Pathology Department, Dental School, Universidade de São Paulo (USP), São Paulo 05508-000, Brazil.
⁹ Laboratory of Comparative and Translational Oncology (LOCT), Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, Universidade de São Paulo (USP), Pirassununga 13635-900, Brazil.
¹⁰ Institute of Health Sciences, Universidade Paulista (UNIP), São Paulo 01533-000, Brazil.
¹¹ Clinical and Surgical Oncology, Vet Cancer Animal Oncology and Pathology, São Paulo 04523-013, Brazil.
¹² Clinical Oncology, Onccarevet e Onconnectionvet, Ribeirão Preto 14026-587, Brasil.
¹³ Técnica Cirúrgica da Pontifícia, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, Brazil.
¹⁴ Clinical and Surgical Oncology, E+ Veterinary Specialties, São Paulo 04078-012, Brazil.
¹⁵ Clinical, Surgical and Palliative Care Oncology, Onco Cane Veterinary, São Paulo 04084-002, Brazil.
¹⁶ Radiation Oncology Service, Pet Care Oncologic Center, São Paulo 05659-010, Brazil.
¹⁷ Naya Specialties, Campo Belo 04608-003, Brazil.
¹⁸ SEOVET-Specialized Service in Veterinary Oncology, Clinical and Surgical Oncology, São Paulo 05016-000, Brazil.
¹⁹ Clinical Oncology and Radiation Therapy, Oncopet Veterinary, Rio de Janeiro 22631-000, Brazil.
²⁰ Department of Animal Medicine, Veterinary School, Universidade Federal do Rio Grande do Sul, Porto Alegre 91540-000, Brazil.
²¹ ONE Patologia Veterinária, Santos 11055-051, Brazil.
²² Small Animal Internal Medicine Department, School of Veterinary Medicine, Universidade Metropolitana de Santos (UNIMES), Santos 11045-002, Brazil.
²³ Department of Veterinary Clinic, School of Veterinary Science and Animal Health, Universidade Estadual Paulista (UNESP), Botucatu 18618-681, Brazil.
²⁴ School of Veterinary, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
²⁵ Surgery Department, Univet Veterinary Clinic-São José Do Rio Preto, São José do Rio Preto 15085-420, Brazil.
²⁶ Vetschool São Paulo: Veterinária, Universidade Estadual Paulista (UNESP), São Paulo 03308-010, Brazil.
²⁷ Surgical and Clinical Oncology, Bota Fogo Veterinary Hospital, Rio de Janeiro 22281-180, Brazil.
²⁸ Eletro-Onkovet Service, Franca 14406-005, Brazil.
²⁹ Department of Surgery, Medical Sciences College, Universidade Estadual de Campinas (UNICAMP), Campinas 13083-970, Brazil.
³⁰ Department of Surgery, School of Veterinary Medicine and Animal Science, Universidade de São Paulo (USP), São Paulo 05508-270, Brazil.
³¹ Veterinary Research Institute (VRI), 621 00 Brno, Czech Republic.
³² Department of Pathology, School of Veterinary Medicine and Animal Science, Universidade de São Paulo (USP), São Paulo 05508-900, Brazil.

Abstract

Mast cell tumors (MCTs) are hematopoietic neoplasms composed of mast cells. It is highly common in dogs and is extremely important in the veterinary oncology field. It represents the third most common tumor subtype, and is the most common malignant skin tumor in dogs, corresponding to 11% of skin cancer cases. The objective of this critical review was to present the report of the 2nd Consensus meeting on the Diagnosis, Prognosis, and Treatment of Canine Cutaneous and Subcutaneous Mast Cell Tumors, which was organized by the Brazilian Association of Veterinary Oncology (ABROVET) in August 2021. The most recent information on cutaneous and subcutaneous mast cell tumors in dogs is presented and discussed.

Keywords: cutaneous; dog; mast cell tumor; subcutaneous.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Dog Diseases* / diagnosis
Dog Diseases* / therapy
Dogs
Mast Cells / pathology
Myeloproliferative Disorders*
Skin Neoplasms* / diagnosis
Skin Neoplasms* / therapy
Skin Neoplasms* / veterinary
Subcutaneous Tissue / pathology