The Relationship Between Diabetes Mellitus and Cancers and Its Underlying Mechanisms

Bing Zhu; Shen Qu

doi:10.3389/fendo.2022.800995

The Relationship Between Diabetes Mellitus and Cancers and Its Underlying Mechanisms

Front Endocrinol (Lausanne). 2022 Feb 11:13:800995. doi: 10.3389/fendo.2022.800995. eCollection 2022.

Authors

Bing Zhu¹, Shen Qu¹

Affiliation

¹ Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Abstract

Epidemiological studies suggest associations between diabetes mellitus and some cancers. The risk of a number of cancers appears to be increased in diabetes mellitus. On the other hand, some cancer and cancer therapies could lead to diabetes mellitus. Genetic factors, obesity, inflammation, oxidative stress, hyperglycemia, hyperinsulinemia, cancer therapies, insulin and some oral hypoglycemic drugs appear to play a role in the crosstalk between diabetes mellitus and cancers. This review summarized the associations between various types of diabetes and cancers and updated available evidence of underlying mechanisms between diabetes and cancers.

Keywords: cancers; mechanism; type 1 diabetes; type 2 diabetes (T2D); type 3C diabetes mellitus.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Diabetes Mellitus, Type 2* / drug therapy
Humans
Hyperglycemia*
Hyperinsulinism*
Insulin / therapeutic use
Neoplasms* / complications
Neoplasms* / epidemiology

Substances

Insulin