Fc effector cross-reactivity: A hidden arsenal against SARS-CoV-2's evasive maneuvering

Cell Rep Med. 2022 Feb 8;3(2):100540. doi: 10.1016/j.xcrm.2022.100540. eCollection 2022 Feb 15.

Abstract

It is unclear whether SARS-CoV-2 VOCs differentially escape Fc effector functions of antibodies in addition to neutralization. In this issue of Cell Reports Medicine, Richardson et al.1 show that VOCs differ both in their ability to evade as well as elicit cross-reactive Fc-effector functions.

MeSH terms

  • Antibodies, Neutralizing / immunology*
  • Antibodies, Viral / immunology*
  • COVID-19 / immunology*
  • COVID-19 / virology
  • Cross Reactions
  • Humans
  • Immune Evasion / genetics*
  • Immunoglobulin Fc Fragments / immunology*
  • Mutation*
  • SARS-CoV-2 / genetics*
  • SARS-CoV-2 / immunology*
  • Spike Glycoprotein, Coronavirus / genetics
  • Spike Glycoprotein, Coronavirus / immunology

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Immunoglobulin Fc Fragments
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2

Supplementary concepts

  • SARS-CoV-2 variants