Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study

Esin Kotiloglu-Karaa; Beatrix Kele; Raghavendran Kulasegaran-Shylini; Claire E Broad; Dola Owoyemi; Joanne Martin; Graham MacPhail; Stamatina Iliodromiti; Anna Riddell; Eliza Alexander; Teresa Cutino-Moguel

doi:10.1093/cid/ciac173

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study

Clin Infect Dis. 2022 Aug 24;75(1):e1176-e1179. doi: 10.1093/cid/ciac173.

Affiliations

¹ Department of Cellular Pathology, The Royal London Hospital, Barts Health, United Kingdom.
² Division of Infection, The Royal London Hospital, Barts Health, United Kingdom.
³ Blizard Institute, Centre for Genomics and Child Health, Queen Mary University, London, United Kingdom.
⁴ Centre for Women's Health, Institute of Population Health Sciences, Queen Mary University London, United Kingdom.

Abstract

We observed an increased frequency of massive perivillous fibrin deposition (MPFD) during the second coronavirus disease 2019 (COVID-19) pandemic wave dominated by the Alpha variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MPFD associated with 100% reverse transcription polymerase chain reaction (RT-PCR) positivity for SARS-CoV-2 and detection by immunohistochemistry. The Alpha variant was identified in all placentas with MPFD that could be sequenced.

Keywords: 2; CoV; SARS; fibrin deposition; placenta.

MeSH terms

COVID-19*
Female
Fibrin / analysis
Humans
Placenta
Pregnancy
Pregnancy Complications, Infectious*
SARS-CoV-2

Substances

Fibrin

Supplementary concepts

SARS-CoV-2 variants