Characterization of PAX5 intragenic tandem multiplication in pediatric B-lymphoblastic leukemia by optical genome mapping

Blood Adv. 2022 Jun 14;6(11):3343-3346. doi: 10.1182/bloodadvances.2021006328.

Authors

Jeffrey Jean¹, Alexandra E Kovach², Andrew Doan^{3

4}, Matthew Oberley⁵, Jianling Ji², Ryan J Schmidt², Jaclyn A Biegel², Deepa Bhojwani^{3

4}, Gordana Raca²

Affiliations

¹ Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
² Department of Pathology and Laboratory Medicine, and.
³ Division of Hematology and Oncology, Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA.
⁴ Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA; and.
⁵ Caris Life Sciences, Phoenix, AZ.

No abstract available

MeSH terms

Child
Chromosome Mapping
Humans
Lymphoma, Non-Hodgkin*
PAX5 Transcription Factor / genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / diagnosis
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics

Substances

PAX5 Transcription Factor
PAX5 protein, human