Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids

J Antibiot (Tokyo). 2022 May;75(5):258-267. doi: 10.1038/s41429-022-00514-w. Epub 2022 Mar 4.

Abstract

A series of lupane-, oleanane- and dammarane-based triterpenoids with 3β-amino, A-ring azepano- and 3,4-seco-fragments has been synthesized and evaluated for antiviral activity against influenza A(H1N1) virus. It was found that azepanodipterocarpol 8 and 3β-amino-28-oxoallobetulin 11 showed antiviral activity with IC50 1.1 and 2.6 μg ml-1, and selectivity index of 19 and 10, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / pharmacology
  • Dammaranes
  • Humans
  • Influenza A Virus, H1N1 Subtype*
  • Influenza, Human* / drug therapy
  • Oleanolic Acid / analogs & derivatives
  • Triterpenes* / pharmacology

Substances

  • Antiviral Agents
  • Triterpenes
  • oleanane
  • lupane
  • Oleanolic Acid