Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Review

Ailiang Miao; Chuanyong Yu; Yulei Sun; Lingling Wang; Jianqing Ge; Xiaoshan Wang

doi:10.3389/fneur.2022.837937

Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Review

Front Neurol. 2022 Feb 18:13:837937. doi: 10.3389/fneur.2022.837937. eCollection 2022.

Authors

Ailiang Miao^{1

2}, Chuanyong Yu^{1

2}, Yulei Sun³, Lingling Wang^{1

2}, Jianqing Ge^{1

2}, Xiaoshan Wang^{1

2}

Affiliations

¹ Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.
² Department of Video-Electroencephalpgram, Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.
³ Department of Neurology, Affiliated Mingji Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

Abstract

Acute cerebellitis associated with Homer-3 antibodies is very rare. Here we present a 20-year-old woman who suffered from uncontrollable head shaking quickly from side to side and an unsteady gait for 2 days after the cold. Antibodies were screened by cell-based assays. The indirect immunofluorescence technique results revealed anti-Homer-3 antibody titers of 1:3.2 in the CSF and 1:100 in the serum. The woman was obviously improved after antiviral and immunosuppression (immunoglobin, methylprednisolone and mycophenolate mofetil) treatment. Our report indicated immune-mediated causes should be considered in the acute cerebellitis. Immunotherapy can contribute to the improvement of cerebellar syndrome.

Keywords: anti-Homer 3 antibody; cerebellar syndrome; cerebellitis; head shaking; immunotherapeutic treatment.

Publication types

Case Reports