Advanced molecular imaging for the characterisation of complex medicines

Drug Discov Today. 2022 Jun;27(6):1716-1723. doi: 10.1016/j.drudis.2022.03.001. Epub 2022 Mar 4.

Abstract

A growing number and diversity of complex medicines is in development and reaching the market, with many of these medicines utilising innovative delivery technology to achieve appropriate biodistribution and exposure. Accurate assessment of biodistribution, cell penetration, internalised form, cargo release and efficacy are essential for the development of these medicines. Advanced imaging technologies, deploying different labelling techniques that allow the assessment of both carrier and cargo, are enabling in-depth analysis and providing a mechanistic understanding of each step in the drug delivery pathway. Translation across cell, tissue and whole-body settings using multiple imaging methods can provide decision-making information that is critical for clinical phase selection and for the development of complex medicines.

Keywords: ADC; Complex medicines; Drug delivery; Microscopy; Molecular imaging; Oligonucleotide.

Publication types

  • Review

MeSH terms

  • Molecular Imaging*
  • Pharmaceutical Preparations
  • Tissue Distribution

Substances

  • Pharmaceutical Preparations