Is rectal filling optimal for MRI-based radiomics in preoperative T staging of rectal cancer?

Purpose: To determine whether rectal filling with ultrasound gel is clinically more beneficial in preoperative T staging of patients with rectal cancer (RC) using radiomics model based on magnetic resonance imaging (MRI).

Methods: A total of 94 RC patients were assigned to cohort 1 (leave-one-out cross-validation [LOO-CV] set) and 230 RC patients were assigned to cohort 2 (test set). Patients were grouped according to different pathological T stages. The radiomics features were extracted through high-resolution T2-weighted imaging for all volume of interests in the two cohorts. Optimal features were selected using the least absolute shrinkage and selection operator (LASSO) algorithm. Model 1 (without rectal filling) and model 2 (with rectal filling) were constructed. LOO-CV was adopted for radiomics model building in cohort 1. Thereafter, the cohort 2 was used to test and verify the effectiveness of the two models.

Results: Totally, 204 patients were enrolled, including 60 cases in cohort 1 and 144 cases in cohort 2. Finally, seven optimal features with LASSO were selected to build model 1 and nine optimal features were used for model 2. The ROC curves showed an AUC of 0.806 and 0.946 for model 1 and model 2 in cohort 1, respectively, and an AUC of 0.783 and 0.920 for model 1 and model 2 in cohort 2, respectively (p = 0.021).

Conclusion: The radiomics model with rectal filling showed an advantage for differentiating T1 + 2 from T3 and had less inaccurate categories in the test cohort, suggesting that this model may be useful for T-stage evaluation.