DNA Methylation: An Important Biomarker and Therapeutic Target for Gastric Cancer

Yunqing Zeng; Huimin Rong; Jianwei Xu; Ruyue Cao; Shuhua Li; Yanjing Gao; Baoquan Cheng; Tao Zhou

doi:10.3389/fgene.2022.823905

DNA Methylation: An Important Biomarker and Therapeutic Target for Gastric Cancer

Front Genet. 2022 Mar 4:13:823905. doi: 10.3389/fgene.2022.823905. eCollection 2022.

Authors

Yunqing Zeng¹, Huimin Rong², Jianwei Xu³, Ruyue Cao¹, Shuhua Li¹, Yanjing Gao¹, Baoquan Cheng¹, Tao Zhou⁴

Affiliations

¹ Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
² Department of Reconstructive Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
³ Department of Pancreatic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
⁴ Department of Geriatric Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Abstract

Gastric cancer (GC) is a very common malignancy with a poor prognosis, and its occurrence and development are closely related to epigenetic modifications. Methylation of DNA before or during gastric cancer is an interesting research topic. This article reviews the studies on DNA methylation related to the cause, diagnosis, treatment, and prognosis of gastric cancer and aims to find cancer biomarkers to solve major human health problems.

Keywords: DNA methylation; diagnosis; gastric cancer; prognosis; therapy.

Publication types

Review