Abstract
Tentative results of a randomized controlled evaluation of the effectiveness of adjuvant hormonal therapy of breast cancer are discussed. The data on 118 cases examined in 1981-1984 were considered on the basis of menstrual cycle characteristics and extension of tumor. The results obtained as a result of an average 16.9 month-long examination pointed to a relatively higher recurrence incidence in untreated patients and suggested that such studies should be continued. Tolerance evaluation established a higher incidence of side-effects in cases treated with diethylstilbestrol (33.3%) than with tamoxifen (3.8%).
Publication types
-
Clinical Trial
-
Comparative Study
-
English Abstract
-
Randomized Controlled Trial
MeSH terms
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Breast Neoplasms / drug therapy*
-
Clinical Trials as Topic
-
Cyclophosphamide / administration & dosage
-
Diethylstilbestrol / adverse effects
-
Diethylstilbestrol / therapeutic use*
-
Female
-
Fluorouracil / administration & dosage
-
Humans
-
Levodopa / therapeutic use
-
Menopause
-
Methotrexate / administration & dosage
-
Middle Aged
-
Neoplasms, Hormone-Dependent
-
Prospective Studies
-
Random Allocation
-
Tamoxifen / adverse effects
-
Tamoxifen / therapeutic use*
Substances
-
Tamoxifen
-
Levodopa
-
Diethylstilbestrol
-
Cyclophosphamide
-
Fluorouracil
-
Methotrexate