Searching for a Link between Bone Decay and Diabetes Type 2

Ciro G Isacco; Kieu C D Nguyen; Van H Pham; Gianna Di Palma; Sergey K Aityan; Diego Tomassone; Pietro Distratis; Rita Lazzaro; Mario G Balzanelli; Francesco Inchingolo

doi:10.2174/1871530322666220324150327

Searching for a Link between Bone Decay and Diabetes Type 2

Endocr Metab Immune Disord Drug Targets. 2022;22(9):904-910. doi: 10.2174/1871530322666220324150327.

Authors

Ciro G Isacco^{1

2

3

4

5

6}, Kieu C D Nguyen⁶, Van H Pham², Gianna Di Palma¹, Sergey K Aityan⁴, Diego Tomassone⁵, Pietro Distratis⁶, Rita Lazzaro⁶, Mario G Balzanelli⁶, Francesco Inchingolo¹

Affiliations

¹ Department of Interdisciplinary Medicine (D.I.M.), Bari University of Medicine Aldo Moro, Bari City, Italy.
² Department of Phan Chau Trinh University of Medicine, Hoi An City, Vietnam.
³ Human Stem Cells Research Center (HSC), Ho Chi Minh City, Vietnam.
⁴ Lincoln University, Oakland, CA, USA.
⁵ Foundation of Physics Research Center (FoPRC), Celico- CS, Italy.
⁶ 118 Pre-Hospital and Emergency Department, SG Moscati Hospital, ASL Taranto, Italy.

PMID: 35331127
DOI: 10.2174/1871530322666220324150327

Abstract

The current commentary describes the possible existing link between metabolic diseases such as diabetes type 2 and the degenerative patterns of bones via the molecular mechanism that inhibits the mesenchymal stem cells' differentiation into osteoblasts and osteocytes.

Keywords: Diabetes type 1-2; ageing; bone decay; bone marrow (BM); central nervous system (CNS); enteric nervous system (ENS); mesenchymal stem cells (MSCs); osteoblasts; regenerative medicine.

MeSH terms

Bone Marrow Cells / metabolism
Cell Differentiation
Diabetes Mellitus, Type 2* / metabolism
Humans
Mesenchymal Stem Cells* / metabolism