Deep Brain Stimulation in a Patient with Parkinson's Disease and Cortical Superficial Siderosis

Intern Med. 2022 Nov 1;61(21):3277-3279. doi: 10.2169/internalmedicine.9253-21. Epub 2022 Mar 26.

Abstract

Cortical superficial siderosis (cSS) is a rare condition that is regarded as a potential magnetic resonance marker of cerebral amyloid angiopathy (CAA). We describe the case of a 68-year-old man with cSS and Parkinson's disease (PD) who subsequently exhibited incidental microhemorrhages, which were only detected on magnetic resonance imaging (MRI), at one week after deep brain stimulation (DBS) surgery. cSS is now considered to be a significant risk factor for CAA and future bleeding. Therefore, because DBS surgery is invasive and may increase the risk of intracerebral hemorrhage, the procedure should be performed carefully when managing patients with PD and CAA.

Keywords: Parkinson's disease; cerebral amyloid angiopathy; cortical superficial siderosis; deep brain stimulation; intracerebral hemorrhage.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Cerebral Amyloid Angiopathy* / complications
  • Cerebral Amyloid Angiopathy* / diagnostic imaging
  • Cerebral Amyloid Angiopathy* / therapy
  • Cerebral Hemorrhage
  • Deep Brain Stimulation* / adverse effects
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Parkinson Disease* / complications
  • Parkinson Disease* / therapy
  • Siderosis* / complications
  • Siderosis* / diagnostic imaging
  • Siderosis* / therapy