C-Nitrosothioformamide: A Donor Template for Dual Release of HNO and H2 S

Shane S Kelly; Xiang Ni; Vivian Yuen; Miles N Radford; Ming Xian

doi:10.1002/cbic.202200101

C-Nitrosothioformamide: A Donor Template for Dual Release of HNO and H₂ S

Chembiochem. 2022 Jul 5;23(13):e202200101. doi: 10.1002/cbic.202200101. Epub 2022 Apr 7.

Authors

Shane S Kelly¹, Xiang Ni², Vivian Yuen², Miles N Radford¹, Ming Xian²

Affiliations

¹ Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
² Department of Chemistry, Brown University, Providence, RI 02912, USA.

Abstract

C-Nitrosothioformamide was demonstrated to be a donor template for dual release of HNO and COS triggered by a retro-Diels-Alder reaction. COS is an H₂ S precursor in the presence of carbonic anhydrase. This process produces HNO and H₂ S in a slow but steady manner. As such, the direct reaction between HNO and H₂ S under this situation appears to be minor. This may provide a useful tool for studying the synergistic effects of HNO and H₂ S.

Keywords: donors; hydrogen sulfide; nitric oxide; nitroxyl; retro-Diels Alder reaction.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Carbonic Anhydrases*
Nitric Oxide
Nitrogen Oxides*

Substances

Nitrogen Oxides
Nitric Oxide
Carbonic Anhydrases

Grants and funding

R01 HL151398/HL/NHLBI NIH HHS/United States