Diagnostic Value of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Patients with Severe COVID-19 - 7 PLADs, China, January 21-February 10, 2020

Yan Ma; Dongshan Zhu; Nannan Shi; Lei Zhang; Guangkun Chen; Youwen Ge; Zelei Zhang; Renbo Chen; Sihong Liu; Yipin Fan; Huamin Zhang; Yanping Wang

doi:10.46234/ccdcw2022.047

Diagnostic Value of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Patients with Severe COVID-19 - 7 PLADs, China, January 21-February 10, 2020

China CDC Wkly. 2022 Mar 11;4(10):195-198. doi: 10.46234/ccdcw2022.047.

Authors

Yan Ma¹, Dongshan Zhu^{2

3}, Nannan Shi⁴, Lei Zhang⁵, Guangkun Chen⁵, Youwen Ge¹, Zelei Zhang⁴, Renbo Chen⁴, Sihong Liu⁵, Yipin Fan¹, Huamin Zhang⁶, Yanping Wang⁴

Affiliations

¹ Department of Infectious Disease Prevention, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
² Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China.
³ Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University [NHC Key Lab of Health Economics and Policy Research (Shandong University)], Jinan, Shandong, China.
⁴ Chinese Medicine Standardization Research Center, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
⁵ Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
⁶ Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Abstract

What is already known about this topic?: Coronavirus disease 2019 (COVID-19) causes symptoms ranging from mild to severe. Indicators for identifying severe COVID-19 infection have not been well identified, especially for young patients.

What is added by this report?: Both neutrophil-lymphocyte ratio (NLR) [area under curve (AUC): 0.80; the odds ratios (OR) and 95% confidence intervals (95% CI): 1.30 (1.13-1.50)] and platelet-lymphocyte ratio (PLR) [AUC: 0.87; OR (95% CI): 1.05 (1.01-1.09)] were determined to be indicators for recognition of patients with severe COVID-19 in young patients less than age 40.

What are the implications for public health practice?: NLR and PLR are useful indicators for identifying patients with severe COVID-19, especially in young patients less than age 40.

Keywords: COVID-19; Neutrophil-lymphocyte ratio; Severe Patient; platelet-lymphocyte ratio.

Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2022.

Grants and funding

Supported by “CACMS Innovation Fund (CI2021A00704), COVID-19 Project of National Administration of Traditional Chinese Medicine (2020ZYLCYJ07-1), COVID-19 project of National Administration of Traditional Chinese Medicine (GZY-KJS-2021-007), the Fundamental Research Funds for the Central public welfare research institutes (Z-0696)”