Comprehensive proteomic profiling of serum extracellular vesicles in patients with colorectal liver metastases identifies a signature for non-invasive risk stratification and early-response evaluation

Affiliations

• ¹ Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
• ² Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
• ³ German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Dresden, Heidelberg, Germany.
• ⁴ Department of Respiratory and Critical Care Medicine, College of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
• ⁵ MS-Based Protein Analysis Unit, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
• ⁶ National Center for Tumor Diseases (NCT/UCC), Partner Site Dresden, Heidelberg, Germany.
• ⁷ MS Center, Centre of Clinical Neuroscience, Department of Neurology, Carl Gustav Carus University Hospital Dresden, Dresden, Germany.
• ⁸ Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.
• ⁹ Klinik Für Allgemein, Viszeral-, Tumor- Und Transplantationschirurgie, Universitätklinikum Köln, Kerpener Str. 62, 50937, Köln, Germany.
• ¹⁰ Diagnostic and Interventional Radiology (DiR), Heidelberg University Hospital, Im Neuenheimer Feld 420, 69120, Heidelberg, Germany.
• ¹¹ Department of Diagnostic and Interventional Radiology, Carl Gustav Carus University Hospital Dresden, Dresden, Germany.
• ¹² Department of Medical Oncology, National Center for Tumour Diseases, Liver Cancer Centre Heidelberg, University Hospital Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
• ¹³ Department of Medicine V, University of Heidelberg, Heidelberg, Germany.
• ¹⁴ German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.
• ¹⁵ Department of Surgery, Medical Faculty Mannheim, University Medicine Mannheim, University of Heidelberg, 68167, Mannheim, Germany. [email protected].
• ¹⁶ Department of Visceral, Thoracic and Vascular Surgery, Carl Gustav Carus University Hospital Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany. [email protected].
• ¹⁷ German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Dresden, Heidelberg, Germany. [email protected].
• ¹⁸ National Center for Tumor Diseases (NCT/UCC), Partner Site Dresden, Heidelberg, Germany. [email protected].