Shock index and modified shock index are predictors of long-term mortality not only in STEMI but also in NSTEMI patients

Timo Schmitz; Eva Harmel; Jakob Linseisen; Inge Kirchberger; Margit Heier; Annette Peters; Christa Meisinger

doi:10.1080/07853890.2022.2056240

Shock index and modified shock index are predictors of long-term mortality not only in STEMI but also in NSTEMI patients

Ann Med. 2022 Dec;54(1):900-908. doi: 10.1080/07853890.2022.2056240.

Authors

Timo Schmitz¹, Eva Harmel², Jakob Linseisen^{1

3}, Inge Kirchberger¹, Margit Heier^{4

5}, Annette Peters^{5

6

7}, Christa Meisinger¹

Affiliations

¹ Chair of Epidemiology, University of Augsburg, University Hospital Augsburg, Augsburg, Germany.
² Department of Cardiology, University Hospital of Augsburg, Augsburg, Germany.
³ IRG Clinical Epidemiology, Helmholtz Zentrum München, Munich Germany.
⁴ KORA Study Centre, University Hospital of Augsburg, Augsburg, Germany.
⁵ Institute of Epidemiology, Helmholtz Zentrum München, Munich Germany.
⁶ Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich Germany.
⁷ German Center for Diabetes Research (DZD), Neuherberg, Germany.

Abstract

Background: Shock index (SI) and modified shock index (mSI) are useful instruments for early risk stratification in acute myocardial infarction (AMI) patients. They are strong predictors for short-term mortality. Nevertheless, the association between SI or mSI and long-term mortality in AMI patients has not yet been sufficiently examined.

Material and methods: For this study, a total of 10,174 patients with AMI was included. All cases were prospectively recorded by the population-based Augsburg Myocardial Infarction Registry from 2000 until 2017. Endpoint was all-cause mortality with a median observational time of 6.5 years [IQR: 3.5-7.4]. Using ROC analysis and calculating Youden-Index, the sample was dichotomized into a low and a high SI and mSI group, respectively. Moreover, multivariable adjusted COX regression models were calculated. All analyses were performed for the total sample as well as for STEMI and NSTEMI cases separately.

Results: Optimal cut-off values were 0.580 for SI and 0.852 for mSI (total sample). AUC values were 0.6382 (95% CI: 0.6223-0.6549) for SI and 0.6552 (95% CI: 0.6397-0.6713) for mSI. Fully adjusted COX regression models revealed significantly higher long-term mortality for patients with high SI and high mSI compared to patients with low indices (high SI HR: 1.42 [1.32-1.52], high mSI HR: 1.46 [1.36-1.57]). Furthermore, the predictive ability was slightly better for mSI compared to SI and more reliable in NSTEMI cases compared to STEMI cases (for SI and mSI).

Conclusion: High SI and mSI are useful tools for early risk stratification including long-term outcome especially in NSTEMI cases, which can help physicians to make decision on therapy. NSTEMI patients with high SI and mSI might especially benefit from immediate invasive therapy.Key messagesShock index and modified shock index are predictors of long-term mortality after acute myocardial infarction.Both indices predict long-term mortality not only for STEMI cases, but even more so for NSTEMI cases.

Keywords: Myocardial infarction; long-term mortality; shock index.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood Pressure
Heart Rate
Humans
Non-ST Elevated Myocardial Infarction* / diagnosis
Retrospective Studies
ST Elevation Myocardial Infarction* / diagnosis

Grants and funding

This work was supported by the Helmholtz Zentrum München, German Research Centre for Environmental Health, which is funded by the German Federal Ministry of Education, Science, Research and Technology and by the State of Bavaria and the German Federal Ministry of Health.