Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs

Lahiru Gangoda; Robyn L Schenk; Lin Tai; Pacman Szeto; Jen G Cheung; Andreas Strasser; Guillaume Lessene; Mark Shackleton; Marco J Herold

doi:10.1038/s41419-022-04776-y

Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs

Cell Death Dis. 2022 Apr 4;13(4):301. doi: 10.1038/s41419-022-04776-y.

Authors

Lahiru Gangoda^{1

2}, Robyn L Schenk^{1

2}, Lin Tai^{1

2}, Pacman Szeto^{3

4}, Jen G Cheung^{3

4}, Andreas Strasser^{1

2}, Guillaume Lessene^{1

2

5}, Mark Shackleton^{3

4}, Marco J Herold^{6

7}

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research (WEHI), 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.
² Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC, 3052, Australia.
³ Department of Oncology, Alfred Health, Melbourne, VIC, 3004, Australia.
⁴ Central Clinical School, Faculty of Medicine, Nursing and Allied Health, Monash University, Melbourne, VIC, Australia.
⁵ Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Melbourne, VIC, 3052, Australia.
⁶ The Walter and Eliza Hall Institute of Medical Research (WEHI), 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia. [email protected].
⁷ Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC, 3052, Australia. [email protected].

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Cell Line, Tumor
Humans
Melanoma* / drug therapy
Methylcellulose
Myeloid Cell Leukemia Sequence 1 Protein
Proto-Oncogene Proteins c-bcl-2*

Substances

Myeloid Cell Leukemia Sequence 1 Protein
Proto-Oncogene Proteins c-bcl-2
Methylcellulose