New insights into the genetic etiology of Alzheimer's disease and related dementias

Affiliations

• ¹ Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. [email protected].
• ² Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
• ³ Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.
• ⁴ Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
• ⁵ Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
• ⁶ Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands.
• ⁷ Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
• ⁸ Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
• ⁹ German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.
• ¹⁰ Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
• ¹¹ CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
• ¹² Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
• ¹³ Nuffield Department of Population Health, Oxford University, Oxford, UK.
• ¹⁴ Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
• ¹⁵ Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
• ¹⁶ Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
• ¹⁷ MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
• ¹⁸ CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
• ¹⁹ Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
• ²⁰ Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
• ²¹ Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
• ²² Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
• ²³ Framingham Heart Study, Framingham, MA, USA.
• ²⁴ Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
• ²⁵ LACDR, Leiden, the Netherlands.
• ²⁶ Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
• ²⁷ Centre of Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
• ²⁸ Institute of Psychiatry, Psychology & Neuroscience, London, UK.
• ²⁹ Department of Surgery, Biochemistry and Molecular Biology, School of Medicine, University of Málaga, Málaga, Spain.
• ³⁰ Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
• ³¹ Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.
• ³² Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain.
• ³³ Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.
• ³⁴ Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain.
• ³⁵ Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
• ³⁶ First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
• ³⁷ Alzheimer Hellas, Thessaloniki, Greece.
• ³⁸ Unidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
• ³⁹ School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
• ⁴⁰ Neurology Unit, San Gerardo Hospital, Monza, Italy.
• ⁴¹ Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.
• ⁴² Department of Laboratory Diagnostics, III Laboratory of Analysis, Brescia Hospital, Brescia, Italy.
• ⁴³ Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
• ⁴⁴ Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain.
• ⁴⁵ Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
• ⁴⁶ Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
• ⁴⁷ NORMENT Centre, University of Oslo, Oslo, Norway.
• ⁴⁸ EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France.
• ⁴⁹ Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
• ⁵⁰ Servei de Neurologia, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
• ⁵¹ Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
• ⁵² Unit of Neurology, University of Parma and AOU, Parma, Italy.
• ⁵³ Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria.
• ⁵⁴ Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.
• ⁵⁵ CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
• ⁵⁶ Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
• ⁵⁷ Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
• ⁵⁸ Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
• ⁵⁹ Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
• ⁶⁰ Neuropsychiatry: Epidemiological and Clinical Research, PSNREC, Université de Montpellier, INSERM U1061, Montpellier, France.
• ⁶¹ Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
• ⁶² Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
• ⁶³ MAC - Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
• ⁶⁴ Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
• ⁶⁵ Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
• ⁶⁶ Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
• ⁶⁷ Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
• ⁶⁸ Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy.
• ⁶⁹ Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
• ⁷⁰ Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.
• ⁷¹ Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
• ⁷² School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
• ⁷³ Dementia Centre for Research Collaboration, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
• ⁷⁴ Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
• ⁷⁵ Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.
• ⁷⁶ Departamento Ciencias Fisiológicas UAII, Facultad de Medicina, UBA, C.A.B.A., Buenos Aires, Argentina.
• ⁷⁷ Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina.
• ⁷⁸ Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
• ⁷⁹ Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.
• ⁸⁰ German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.
• ⁸¹ Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand.
• ⁸² Wales Centre for Ageing & Dementia Research, Swansea University, Wales, New Zealand.
• ⁸³ Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
• ⁸⁴ UFIEC, Instituto de Salud Carlos III, Madrid, Spain.
• ⁸⁵ Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ⁸⁶ INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.
• ⁸⁷ Pole Santé Publique, CHU de Bordeaux, Bordeaux, France.
• ⁸⁸ Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA.
• ⁸⁹ Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA.
• ⁹⁰ Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
• ⁹¹ Fundación Pública Galega de Medicina Xenómica- CIBERER-IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain.
• ⁹² Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
• ⁹³ Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.
• ⁹⁴ Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA.
• ⁹⁵ Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy.
• ⁹⁶ Radboudumc Alzheimer Center, Department of Geriatrics, Radboud University Medical Center, Nijmegen, the Netherlands.
• ⁹⁷ Institute for Regenerative Medicine, University of Zürich, Schlieren, Switzerland.
• ⁹⁸ Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
• ⁹⁹ Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
• ¹⁰⁰ University of Bari, "A. Moro", Bary, Italy.
• ¹⁰¹ School of Medicine, University of Thessaly, Larissa, Greece.
• ¹⁰² Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France.
• ¹⁰³ Department of Neurology, University Medical Center Groningen, Groningen, the Netherlands.
• ¹⁰⁴ Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ¹⁰⁵ Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ¹⁰⁶ Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ¹⁰⁷ Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ¹⁰⁸ Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.
• ¹⁰⁹ UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK.
• ¹¹⁰ Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
• ¹¹¹ Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
• ¹¹² Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany.
• ¹¹³ Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.
• ¹¹⁴ German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
• ¹¹⁵ Icelandic Heart Association, Kopovagur, Iceland.
• ¹¹⁶ Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
• ¹¹⁷ Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
• ¹¹⁸ Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
• ¹¹⁹ Department of Neurology, UZ Brussel, Brussels, Belgium.
• ¹²⁰ Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
• ¹²¹ Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy.
• ¹²² Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.
• ¹²³ Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA.
• ¹²⁴ Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.
• ¹²⁵ University of Milan, Milan, Italy.
• ¹²⁶ Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, USA.
• ¹²⁷ Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
• ¹²⁸ Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
• ¹²⁹ Department of Psychiatry, Social Medicine Center East- Donauspital, Vienna, Austria.
• ¹³⁰ Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
• ¹³¹ Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
• ¹³² Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
• ¹³³ Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
• ¹³⁴ Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.
• ¹³⁵ Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain.
• ¹³⁶ Hospital Universitario la Paz, Madrid, Spain.
• ¹³⁷ Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany.
• ¹³⁸ Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ¹³⁹ Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain.
• ¹⁴⁰ Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.
• ¹⁴¹ Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
• ¹⁴² Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ¹⁴³ CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.
• ¹⁴⁴ Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
• ¹⁴⁵ Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.
• ¹⁴⁶ Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
• ¹⁴⁷ Institute of Public Health, University of Cambridge, Cambridge, UK.
• ¹⁴⁸ Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.
• ¹⁴⁹ Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
• ¹⁵⁰ Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
• ¹⁵¹ Icelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
• ¹⁵² Human Genetics, School of Life Sciences, Life Sciences Building, University Park, University of Nottingham, Nottingham, UK.
• ¹⁵³ AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
• ¹⁵⁴ Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
• ¹⁵⁵ The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
• ¹⁵⁶ GRC 21, Alzheimer Precision Medicine Initiative (APMI), Sorbonne University, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
• ¹⁵⁷ Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
• ¹⁵⁸ Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.
• ¹⁵⁹ Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
• ¹⁶⁰ Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, UK.
• ¹⁶¹ Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ¹⁶² Department of Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands.
• ¹⁶³ Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA.
• ¹⁶⁴ Department of Biology, Brigham Young University, Provo, UT, USA.
• ¹⁶⁵ Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
• ¹⁶⁶ Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
• ¹⁶⁷ Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
• ¹⁶⁸ Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK.
• ¹⁶⁹ Research & Development, UnitStockholms Sjukhem, Stockholm, Sweden.
• ¹⁷⁰ Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
• ¹⁷¹ Department of Neurosciences, University of Helsinki and Department of Geriatrics, Helsinki University Hospital, Helsinki, Finland.
• ¹⁷² Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
• ¹⁷³ Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
• ¹⁷⁴ Department of Epidemiology, University of Washington, Seattle, WA, USA.
• ¹⁷⁵ Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain.
• ¹⁷⁶ Stockholm Gerontology Research Center, Stockholm, Sweden.
• ¹⁷⁷ Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, MD, USA.
• ¹⁷⁸ Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA.
• ¹⁷⁹ Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
• ¹⁸⁰ Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.
• ¹⁸¹ International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czechia.
• ¹⁸² Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA.
• ¹⁸³ Department of Neurology, Hospital Universitario Donostia, OSAKIDETZA-Servicio Vasco de Salud, San Sebastian, Spain.
• ¹⁸⁴ Department of Neurology, Columbia University, New York, NY, USA.
• ¹⁸⁵ School of Health Sciences, Bangor University, Bangor, UK.
• ¹⁸⁶ Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy.
• ¹⁸⁷ Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
• ¹⁸⁸ MRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
• ¹⁸⁹ Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
• ¹⁹⁰ Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany.
• ¹⁹¹ Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
• ¹⁹² Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain.
• ¹⁹³ Laboratory of Brain Aging and Neurodegeneration, FIL-CONICET, Buenos Aires, Argentina.
• ¹⁹⁴ Human Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK.
• ¹⁹⁵ Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
• ¹⁹⁶ Laboratorio de Bioquímica Molecular, Facultad de Medicina, Instituto de Investigaciones Médicas A. Lanari, UBA, C.A.B.A, Buenos Aires, Argentina.
• ¹⁹⁷ Department of Medicine, University of Washington, Seattle, WA, USA.
• ¹⁹⁸ IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
• ¹⁹⁹ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
• ²⁰⁰ DIMEC, University of Parma, Parma, Italy.
• ²⁰¹ Resources and Research Memory Center (MRRC) of Distalz, LicendUniversity of Lille, INSERM, CHU Lille, UMR1172, Lille, France.
• ²⁰² Institut de Biomedicina de València-CSIC CIBERNED, València, Spain.
• ²⁰³ Unitat Mixta de de Neurología y Genética, Institut d'Investigació Sanitària La Fe, València, Spain.
• ²⁰⁴ US 41-UMS 2014-PLBS, bilille, Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Lille, France.
• ²⁰⁵ Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.
• ²⁰⁶ German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
• ²⁰⁷ Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
• ²⁰⁸ CHUV, Old Age Psychiatry, Department of Psychiatry, Lausanne, Switzerland.
• ²⁰⁹ Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.
• ²¹⁰ Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland.
• ²¹¹ Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité, Charitéplatz 1, Berlin, Germany.
• ²¹² Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
• ²¹³ Department of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands.
• ²¹⁴ Depatamento de Especialidades Quirúrgicas Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain.
• ²¹⁵ Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands.
• ²¹⁶ Taub Institute, Columbia University, New York, NY, USA.
• ²¹⁷ Bioinformatics, College of Life Sciences, Brigham Young University, Provo, UT, USA.
• ²¹⁸ Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
• ²¹⁹ Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Wuerzburg, Germany.
• ²²⁰ Department of Research and Innovation, Helse Fonna, Haugesund Hospital, Haugesund, Norway.
• ²²¹ Institute of Clinical Medicine (K1), The University of Bergen, Bergen, Norway.
• ²²² Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga, Málaga, Spain.
• ²²³ Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy.
• ²²⁴ Athens Association of Alzheimer's Disease and Related Disorders, Athens, Greece.
• ²²⁵ Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
• ²²⁶ Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain.
• ²²⁷ Neurology Department-Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.
• ²²⁸ First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
• ²²⁹ LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
• ²³⁰ Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
• ²³¹ Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
• ²³² Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
• ²³³ Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy.
• ²³⁴ Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Hospital Clínico San Carlos, Madrid, Spain.
• ²³⁵ Department of Neurology, University of Bonn, Bonn, Germany.
• ²³⁶ Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
• ²³⁷ Department of Psychiatry, Namsos Hospital, Namsos, Norway.
• ²³⁸ Department of Internal Medicine and Biostatistics, Erasmus MC, Rotterdam, the Netherlands.
• ²³⁹ Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
• ²⁴⁰ Department of Neurology, ErasmusMC, Rotterdam, the Netherlands.
• ²⁴¹ Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Leuven, Belgium.
• ²⁴² Neurology Department, University Hospitals Leuven, Leuven, Belgium.
• ²⁴³ Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.
• ²⁴⁴ Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.
• ²⁴⁵ Department of Neurology and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.
• ²⁴⁶ German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.
• ²⁴⁷ Medical Science Department, iBiMED, Aveiro, Portugal.
• ²⁴⁸ Department of Nutrition and Diatetics, Harokopio University, Athens, Greece.
• ²⁴⁹ Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
• ²⁵⁰ Neurosciences Area, Instituto Biodonostia, San Sebastian, Spain.
• ²⁵¹ Department of Health Service, University of Washington, Seattle, WA, USA.
• ²⁵² Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
• ²⁵³ Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. [email protected].