Genetic variants associated with longitudinal changes in brain structure across the lifespan

Affiliations

• ¹ Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands. [email protected].
• ² Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands. [email protected].
• ³ Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
• ⁴ Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
• ⁵ Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
• ⁶ Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
• ⁷ Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
• ⁸ Utrecht Institute of Linguistics OTS, Utrecht University, Utrecht, The Netherlands.
• ⁹ Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
• ¹⁰ Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
• ¹¹ Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
• ¹² American Psychiatric Association, Washington, DC, USA.
• ¹³ VA San Diego Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
• ¹⁴ Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
• ¹⁵ Biogen Research and Development, Cambridge, MA, USA.
• ¹⁶ Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
• ¹⁷ Institute of Education & Child Studies, Section Forensic Family & Youth Care, Leiden University, Leiden, The Netherlands.
• ¹⁸ Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain.
• ¹⁹ NORMENT Centre, University of Oslo, Oslo, Norway.
• ²⁰ Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
• ²¹ INSERM U1299 Trajectoires Développementales en Psychiatrie, Ecole Normale Supérieure Paris-Saclay, Université Paris Saclay, Université Paris Cité, CNRS UMR 9010; Centre Borelli, Gif-sur-Yvette, France.
• ²² Valdecilla Biomedical Research Institute (IDIVAL), Marqués de Valdecilla University Hospital (HUMV), School of Medicine, University of Cantabria, Santander, Spain.
• ²³ CIBERSAM, Biomedical Research Network on Mental Health Area, Santander, Spain.
• ²⁴ Universidad de Cantabria, Santander, Spain.
• ²⁵ Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
• ²⁶ Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.
• ²⁷ Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
• ²⁸ Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.
• ²⁹ Department of Child and Adolescent Psychiatry/Psychology, Sophia Children's Hospital, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
• ³⁰ Psychosomatic and CL Psychiatry, Oslo University Hospital, Oslo, Norway.
• ³¹ Brain Dynamics Centre, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW, Australia.
• ³² Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
• ³³ Centre for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
• ³⁴ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
• ³⁵ Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
• ³⁶ Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
• ³⁷ Department of Neurology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
• ³⁸ Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
• ³⁹ Institute for Translational Psychiatry, University of Münster, Münster, Germany.
• ⁴⁰ Section of Systems Neuroscience, Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
• ⁴¹ Université Paris-Saclay, CEA, Neurospin, Gif-sur-Yvette, France.
• ⁴² University of Groningen, University Medical Center Groningen, Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), Groningen, The Netherlands.
• ⁴³ Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
• ⁴⁴ Clinic for Radiology, University Hospital Münster, Münster, Germany.
• ⁴⁵ Departments of Experimental and Clinical Psychology, Amsterdam, The Netherlands.
• ⁴⁶ Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
• ⁴⁷ Physikalisch-Technische Bundesanstalt, Berlin, Germany.
• ⁴⁸ Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.
• ⁴⁹ Department of Human Genetics, VUmc, Amsterdam UMC, Amsterdam, The Netherlands.
• ⁵⁰ Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Science and Technology for Brain-Inspired Intelligence and MoE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China.
• ⁵¹ Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, SGDP Centre, King's College London, London, UK.
• ⁵² Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia.
• ⁵³ Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
• ⁵⁴ Institute for Anatomy I, Medical Faculty & University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.
• ⁵⁵ Department of Psychiatry and Psychotherapy, University Hospital LMU, Munich, Germany.
• ⁵⁶ NeuroImaging Core Unit Munich (NICUM), University Hospital LMU, Munich, Germany.
• ⁵⁷ Munich Center for Neurosciences (MCN) - Brain & Mind, Planegg-Martinsried, Germany.
• ⁵⁸ School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
• ⁵⁹ School of Psychiatry and Behavioral Sciences, School of Medicine, University of New Mexico, Albuquerque, NM, USA.
• ⁶⁰ Neuroscience Research Australia, Sydney, NSW, Australia.
• ⁶¹ Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
• ⁶² Institute for Translational Neuroscience, University of Münster, Münster, Germany.
• ⁶³ School of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand.
• ⁶⁴ Brain Research New Zealand - Rangahau Roro Aotearoa, Auckland, New Zealand.
• ⁶⁵ Cécile and Oskar Vogt Institute for Brain Research, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
• ⁶⁶ Department of Biomedicine, University of Basel, Basel, Switzerland.
• ⁶⁷ Department of Psychiatry, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany.
• ⁶⁸ Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain.
• ⁶⁹ APHP, Sorbonne Université, Pitie-Salpetriere Hospital, Department of Child and Adolescent Psychiatry, Paris, France.
• ⁷⁰ Department of Psychology, University of Halle, Halle, Germany.
• ⁷¹ Psychiatric Imaging Group, MRC London Institute of Medical Sciences (LMS), Imperial College London, London, UK.
• ⁷² Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
• ⁷³ Department of Radiology & Nuclear Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands.
• ⁷⁴ Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
• ⁷⁵ Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, MD, USA.
• ⁷⁶ Department of Neuropsychiatry, Wakayama Medical University, Wakayama, Japan.
• ⁷⁷ Department of Radiology, IDIVAL, Marqués de Valdecilla University Hospital, Santander, Spain.
• ⁷⁸ Advanced Computing and e-Science, Instituto de Física de Cantabria (UC-CSIC), Santander, Spain.
• ⁷⁹ Centre for Clinical Brain Sciences and UK Dementia Research Institute Centre, University of Edinburgh, Edinburgh, UK.
• ⁸⁰ Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
• ⁸¹ German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
• ⁸² Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
• ⁸³ Laboratory of Integrative Neuroscience (LiNC), Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
• ⁸⁴ National Institute of Developmental Psychiatry for Children and Adolescents (INPD), CNPq, São Paulo, Brazil.
• ⁸⁵ Mathematics and Statistics, Curtin University, Perth, WA, Australia.
• ⁸⁶ Department of Psychology, University of Edinburgh, Edinburgh, UK.
• ⁸⁷ Centre for Neuroimaging, Cognition and Genomics (NICOG), School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, Ireland.
• ⁸⁸ Centre for Human Genetics, Philipps-University Marburg, Marburg, Germany.
• ⁸⁹ Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
• ⁹⁰ Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
• ⁹¹ Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
• ⁹² Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
• ⁹³ School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
• ⁹⁴ NORMENT Centre of Excellence, Department of Clinical Science, University of Bergen, Bergen, Norway.
• ⁹⁵ Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.
• ⁹⁶ Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital LMU, Munich, Germany.
• ⁹⁷ Department of Genetic Epidemiology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
• ⁹⁸ Department of Morphology and Genetics, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
• ⁹⁹ Department of Genetics & UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
• ¹⁰⁰ Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
• ¹⁰¹ School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
• ¹⁰² NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
• ¹⁰³ Department of Clinical Genetics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
• ¹⁰⁴ Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
• ¹⁰⁵ Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
• ¹⁰⁶ Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
• ¹⁰⁷ Academic Unit for Psychiatry of Old Age, University of Melbourne, Parkville, VIC, Australia.
• ¹⁰⁸ National Ageing Research Institute, Parkville, VIC, Australia.
• ¹⁰⁹ Department of Psychiatry, University of Melbourne, Melbourne VIC, Australia.
• ¹¹⁰ Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.
• ¹¹¹ Department of Psychiatry, University of Münster, Münster, Germany.
• ¹¹² Discipline of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
• ¹¹³ Instituto Ame Sua Mente, São Paulo, Brazil.
• ¹¹⁴ Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands.
• ¹¹⁵ Altrecht Science, Altrecht Mental Health Institute, Utrecht, The Netherlands.
• ¹¹⁶ Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
• ¹¹⁷ Department of Psychiatry, Virgen del Rocio University Hospital, School of Medicine, University of Seville, IBIS, Seville, Spain.
• ¹¹⁸ Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK.
• ¹¹⁹ NORMENT Centre, Oslo University Hospital, Oslo, Norway.
• ¹²⁰ Department of Neurology, Oslo University Hospital, Oslo, Norway.
• ¹²¹ Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
• ¹²² Department of Psychology, University of Oslo, Oslo, Norway.
• ¹²³ Bjørknes College, Oslo, Norway.
• ¹²⁴ Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
• ¹²⁵ Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
• ¹²⁶ Department of Psychiatry, University of Vermont, Burlington, VT, USA.
• ¹²⁷ Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
• ¹²⁸ Charité Universitätsmedizin Berlin, Berlin, Germany.
• ¹²⁹ Faculty of Health, Peninsula Medical School, University of Plymouth, Plymouth, UK.
• ¹³⁰ University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry & Accare Child Study Center, Groningen, The Netherlands.
• ¹³¹ Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Marburg, Germany.
• ¹³² Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• ¹³³ VISN 2 Mental Illness Research, Education & Clinical Center (MIRECC), James J. Peters Department of Veterans Affairs Medical Center, Bronx, NY, USA.
• ¹³⁴ Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
• ¹³⁵ Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université de Bordeaux, Centre Broca Nouvelle-Aquitaine, Bordeaux, France.
• ¹³⁶ Unit for Psychosomatic Medicine and C-L Psychiatry, University of Oslo, Oslo, Norway.
• ¹³⁷ Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany.
• ¹³⁸ Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, Department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands.
• ¹³⁹ Vrije Universiteit, Clinical Neuropsychology Section, Amsterdam, The Netherlands.
• ¹⁴⁰ Department of Psychiatry, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands.
• ¹⁴¹ Department of Child and Adolescent Psychiatry, University Medical Center Goettingen, Göttingen, Germany.
• ¹⁴² Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, NSW, Australia.
• ¹⁴³ Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
• ¹⁴⁴ Section on Negative Affect and Social Processes, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
• ¹⁴⁵ Center for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology for Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China.
• ¹⁴⁶ PONS Centre, Department of Psychiatry and Clinical Neuroscience, CCM, Charite University Medicine, Berlin, Germany.
• ¹⁴⁷ National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
• ¹⁴⁸ West Region, Institute of Mental Health, Singapore, Singapore.
• ¹⁴⁹ Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
• ¹⁵⁰ Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
• ¹⁵¹ SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
• ¹⁵² Department of Developmental Disability Neuropsychiatry, Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia.
• ¹⁵³ Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute for Health, Berlin, Germany.
• ¹⁵⁴ Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
• ¹⁵⁵ Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
• ¹⁵⁶ Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia.
• ¹⁵⁷ QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
• ¹⁵⁸ Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
• ¹⁵⁹ Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands. [email protected].
• ¹⁶⁰ Department of Psychology, Utrecht University, Utrecht, The Netherlands. [email protected].