Human papillomavirus-related oropharyngeal carcinoma

Yuki Saito; Akihiro Homma; Naomi Kiyota; Makoto Tahara; Nobuhiro Hanai; Takahiro Asakage; Kazuto Matsuura; Ichiro Ota; Tomoya Yokota; Daisuke Sano; Takeshi Kodaira; Atsushi Motegi; Koichi Yasuda; Shunji Takahashi; Kaoru Tanaka; Takuma Onoe; Susumu Okano; Yoshinori Imamura; Yosuke Ariizumi; Ryuichi Hayashi

doi:10.1093/jjco/hyac049

Human papillomavirus-related oropharyngeal carcinoma

Jpn J Clin Oncol. 2022 Jul 8;52(7):700-706. doi: 10.1093/jjco/hyac049.

Authors

Yuki Saito¹, Akihiro Homma², Naomi Kiyota³, Makoto Tahara⁴, Nobuhiro Hanai⁵, Takahiro Asakage⁶, Kazuto Matsuura⁷, Ichiro Ota⁸, Tomoya Yokota⁹, Daisuke Sano¹⁰, Takeshi Kodaira¹¹, Atsushi Motegi¹², Koichi Yasuda¹³, Shunji Takahashi¹⁴, Kaoru Tanaka¹⁵, Takuma Onoe¹⁶, Susumu Okano⁴, Yoshinori Imamura³, Yosuke Ariizumi⁶, Ryuichi Hayashi⁷

Affiliations

¹ Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Tokyo, Japan.
² Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
³ Department of Medical Oncology and Hematology, Cancer Center, Kobe University Hospital, Kobe, Japan.
⁴ Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
⁵ Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
⁶ Department of Head and Neck Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
⁷ Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
⁸ Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Nara, Japan.
⁹ Divisions of Gastrointestinal Oncology, Shizuoka Cancer Center, Kashiwa, Japan.
¹⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University, School of Medicine, Yokohama, Japan.
¹¹ Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.
¹² Department of Radiation Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
¹³ Department of Radiation Oncology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
¹⁴ Department of Medical Oncology, Cancer Institute Hospital, Tokyo, Japan.
¹⁵ Department of Medical Oncology, Kindai University Faculty of Medicine, Higashi-Osaka, Japan.
¹⁶ Division of Medical Oncology, Hyogo Cancer Center, Hyogo, Japan.

PMID: 35383359
DOI: 10.1093/jjco/hyac049

Abstract

It was not until around 2000 that human papillomavirus-related oropharyngeal carcinoma was recognized as carcinoma with clinical presentations different from nonrelated head and neck carcinoma. Twenty years after and with the revision of the tumor-node-metastasis classification in 2017, various clinical trials focused on human papillomavirus-related oropharyngeal carcinoma to improve the prognosis and quality of life of patients with this disease. However, the incidence of human papillomavirus-related cancers is increasing, which is expected to be particularly prominent in Japan, where human papillomavirus vaccination is not widely available. In this review, we describe the current status of clinical trials (mainly focused on initial surgery and radiation dose reduction) for, primary and secondary prevention of, and the present status of human papillomavirus-related oropharyngeal carcinoma in Japan.

Keywords: HNSCC; Japan; human papillomavirus; oropharyngeal carcinoma; p16.

Publication types

Review

MeSH terms

Alphapapillomavirus*
Carcinoma, Squamous Cell* / pathology
Head and Neck Neoplasms*
Humans
Oropharyngeal Neoplasms* / pathology
Oropharyngeal Neoplasms* / therapy
Papillomaviridae
Papillomavirus Infections* / complications
Papillomavirus Vaccines* / therapeutic use
Quality of Life

Substances

Papillomavirus Vaccines

Grants and funding

2020-J-3/National Cancer Center Research and Development