Point-of-care diagnostic tests for tuberculosis disease

Jia Mei Hong; Hyeyoung Lee; Nishanth V Menon; Chwee Teck Lim; Luke P Lee; Catherine W M Ong

doi:10.1126/scitranslmed.abj4124

Point-of-care diagnostic tests for tuberculosis disease

Sci Transl Med. 2022 Apr 6;14(639):eabj4124. doi: 10.1126/scitranslmed.abj4124. Epub 2022 Apr 6.

Authors

Jia Mei Hong¹, Hyeyoung Lee¹, Nishanth V Menon², Chwee Teck Lim^{2

3

4}, Luke P Lee^{5

6

7

8

9

10}, Catherine W M Ong^{1

3}

Affiliations

¹ Infectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
² Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.
³ Institute for Health Innovation & Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore.
⁴ Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.
⁵ Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
⁶ Berkeley Sensor and Actuator Center, University of California, Berkeley, Berkeley, CA 94720-1764, USA.
⁷ Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA 94720, USA.
⁸ Biophysics Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
⁹ Harvard Medical School, Brigham and Women's Hospital, Harvard Institute of Medicine, Harvard University, Boston, MA 02115, USA.
¹⁰ Institute of Quantum Biophysics, Department of Biophysics, Sungkyunkwan University, Suwon, Korea.

PMID: 35385338
DOI: 10.1126/scitranslmed.abj4124

Abstract

Rapid diagnosis is one key pillar to end tuberculosis (TB). Point-of-care tests (POCTs) facilitate early detection, immediate treatment, and reduced transmission of TB disease. This Review evaluates current diagnostic assays endorsed by the World Health Organization and identifies the gaps between existing conventional tests and the ideal POCT. We discuss the commercial development of new rapid tests and research studies on nonsputum-based diagnostic biomarkers from both pathogen and host. Last, we highlight advances in integrated microfluidics technology that may aid the development of new POCTs.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Microfluidics
Point-of-Care Systems
Point-of-Care Testing
Tuberculosis* / diagnosis
World Health Organization