A new lanostane triterpenoid from the mushroom Hypholoma fasciculare

Junhong Wang; Jing Wu; Kenta Tsutsumi; Jae-Hoon Choi; Hirofumi Hirai; Hajime Kobori; Yuichi Takikawa; Hirokazu Kawagishi

doi:10.1093/bbb/zbac050

A new lanostane triterpenoid from the mushroom Hypholoma fasciculare

Biosci Biotechnol Biochem. 2022 Jun 25;86(7):819-823. doi: 10.1093/bbb/zbac050.

Authors

Junhong Wang¹, Jing Wu², Kenta Tsutsumi³, Jae-Hoon Choi^{1

2

3

4}, Hirofumi Hirai^{1

2

3

4}, Hajime Kobori⁵, Yuichi Takikawa^{1

3

4}, Hirokazu Kawagishi^{1

2

3

4}

Affiliations

¹ Department of Agriculture, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan.
² Research Institute of Green Science and Technology, Shizuoka University, Shizuoka, Japan.
³ Department of Applied Life Science, Faculty of Agriculture, Shizuoka University, Shizuoka, Japan.
⁴ Department of Bioscience, Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.
⁵ Iwade Research Institute of Mycology Co., Ltd., Tsu-shi, Mie, Japan.

PMID: 35388876
DOI: 10.1093/bbb/zbac050

Abstract

A novel compound (1) and 3 known compounds (2-4) were isolated from the fruiting bodies of Hypholoma fasciculare. The structure of 1 was determined by the interpretation of spectroscopic data. Compounds 2-4 were identified by comparing the spectra data of known compounds. In the bioassay examining growth inhibitory activity against phytopathogenic bacteria Clavibacter michiganensis, Burkholderia glumae, and Peptobacterium carotovorum, compounds 1, 2, and 4 showed inhibition effects on C. michiganensis only.

Keywords: Hypholoma fasciculare; isolation; mushroom; phytopathogenic bacterial activity; structural determination.

MeSH terms

Agaricales* / chemistry
Fruiting Bodies, Fungal / chemistry
Molecular Structure
Steroids
Triterpenes*

Substances

Steroids
Triterpenes

Supplementary concepts

Hypholoma fasciculare

Grants and funding

17H06402/Ministry of Education, Culture, Sports, Science and Technology