The role of ubiquitination and deubiquitination in tumor invasion and metastasis

Shuangze Han; Ruike Wang; Yangnan Zhang; Xiaoying Li; Yu Gan; Feng Gao; Pengfei Rong; Wei Wang; Wei Li

doi:10.7150/ijbs.69411

The role of ubiquitination and deubiquitination in tumor invasion and metastasis

Int J Biol Sci. 2022 Mar 6;18(6):2292-2303. doi: 10.7150/ijbs.69411. eCollection 2022.

Authors

Shuangze Han¹, Ruike Wang¹, Yangnan Zhang¹, Xiaoying Li¹, Yu Gan¹, Feng Gao², Pengfei Rong^{1

3}, Wei Wang^{1

3}, Wei Li^{1

3}

Affiliations

¹ Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
² Department of Ultrasonography, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China.
³ Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.

Abstract

Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis. This review will briefly summarize the observations and underlying mechanisms of multiple E3 ubiquitin ligases and deubiquitinases to regulate tumor metastasis. Further, we will discuss the relationship and importance between ubiquitination components and tumor progression.

Keywords: E3 ubiquitin ligase; deubiquitinase; metastasis; ubiquitination.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Deubiquitinating Enzymes / metabolism
Humans
Neoplasms* / metabolism
Ubiquitin / metabolism
Ubiquitin-Protein Ligases* / genetics
Ubiquitin-Protein Ligases* / metabolism
Ubiquitination

Substances

Ubiquitin
Ubiquitin-Protein Ligases
Deubiquitinating Enzymes