Expelliarmus helminthus! Harry Helminth and the Goblet of Alarmins

Heike C Hawerkamp; Padraic G Fallon

doi:10.1016/j.immuni.2022.03.014

Expelliarmus helminthus! Harry Helminth and the Goblet of Alarmins

Immunity. 2022 Apr 12;55(4):575-577. doi: 10.1016/j.immuni.2022.03.014.

Authors

Heike C Hawerkamp¹, Padraic G Fallon²

Affiliations

¹ School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: [email protected].
² School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: [email protected].

PMID: 35417668
DOI: 10.1016/j.immuni.2022.03.014

Abstract

Epithelial cells (tuft and goblet cells) interact with immune cells on the "inside" while secreting effector molecules into the topological "outside." In this issue of Immunity, Zhao et al. investigate an interleukin-33 (IL-33) secretion mechanism in goblet cells dependent on O-GlcNAcylation and gasdermin pores facilitating worm expulsion.

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MeSH terms

Alarmins*
Animals
Epithelial Cells
Goblet Cells
Interleukin-13
Nippostrongylus*

Substances

Alarmins
Interleukin-13