Autosomal Dominant Polycystic Kidney Disease Prevalence among a Racially Diverse United States Population, 2002 through 2018

Thet T Aung; Simran K Bhandari; Qiaoling Chen; Fatima T Malik; Cynthia J Willey; Kristi Reynolds; Steven J Jacobsen; John J Sim

doi:10.34067/KID.0004522021

Autosomal Dominant Polycystic Kidney Disease Prevalence among a Racially Diverse United States Population, 2002 through 2018

Kidney360. 2021 Sep 22;2(12):2010-2015. doi: 10.34067/KID.0004522021. eCollection 2021 Dec 30.

Authors

Thet T Aung¹, Simran K Bhandari^{2

3}, Qiaoling Chen⁴, Fatima T Malik¹, Cynthia J Willey⁵, Kristi Reynolds^{3

4}, Steven J Jacobsen⁴, John J Sim^{1

3}

Affiliations

¹ Division of Nephrology and Hypertension, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California.
² Department of Internal Medicine, Kaiser Permanente Downey Medical Center, Downey, California.
³ Departments of Health Systems and Clinical Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California.
⁴ Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
⁵ College of Pharmacy, University of Rhode Island, Kingston, Rhode Island.

Abstract

Among a large racially and ethnically diverse US population, the prevalence of diagnosed ADPKD between 2002 and 2018 was 42.6 per 100,000 persons.ADPKD prevalence (per 100,000) was higher in (non-Hispanic) White (63.2) and Black (73.0) patients compared with Hispanic (39.9) and Asian (48.9) patients.Given the variable penetrance of ADPKD, our findings suggest race may be a factor in the clinical presentation and diagnosis of ADPKD.

Keywords: United States; autosomal dominant polycystic kidney; autosomal dominant polycystic kidney disease; cystic kidney disease; electronic health records; epidemiology; genetic kidney disease; prevalence; racial/ethnic diversity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ethnicity
Female
Humans
Male
Polycystic Kidney, Autosomal Dominant* / diagnosis
Prevalence
United States / epidemiology