Cobalt-catalyzed annulation of styrenes with α-bromoacetic acids

RSC Adv. 2021 Jan 29;11(10):5451-5455. doi: 10.1039/d0ra09588e. eCollection 2021 Jan 28.

Abstract

We report a method for addition of α-bromophenylacetic acids to vinyl C[double bond, length as m-dash]C bonds in styrenes to afford γ-lactones. Reactions employed a simple cobalt catalyst Co(NO3)2·6H2O in the presence of dipivaloylmethane (dpm) ligand. Many functionalities including halogen, ester, and nitro groups were compatible with reaction conditions. If α-bromoesters were used, vinylacetates were the major products.