Redefining inflammatory macrophage phenotypes across stages and tissues by single-cell transcriptomics

Sci Immunol. 2022 Apr 15;7(70):eabo4652. doi: 10.1126/sciimmunol.abo4652. Epub 2022 Apr 15.

Authors

P'ng Loke¹, Jian-Da Lin^{2

3}

Affiliations

¹ Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
² Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei City 10617, Taiwan.
³ Center for Computational and Systems Biology, National Taiwan University, Taipei City 10617, Taiwan.

PMID: 35427177
DOI: 10.1126/sciimmunol.abo4652

Abstract

Single-cell transcriptomic data identifies major activation paths of monocyte-derived macrophages as a framework for inflammatory tissue macrophages.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Comment

MeSH terms

Macrophages*
Phenotype
Transcriptome*