Hormone Treatment of Prostate Cancer:: Evidence for Usage and Safety

Muhieddine Labban; Marwan Alkassis; Khalid Alkhatib; Logan Briggs; Alexander P Cole; Adam S Kibel; Quoc-Dien Trinh

doi:10.1016/j.ucl.2022.01.001

Hormone Treatment of Prostate Cancer:: Evidence for Usage and Safety

Urol Clin North Am. 2022 May;49(2):309-321. doi: 10.1016/j.ucl.2022.01.001.

Authors

Muhieddine Labban¹, Marwan Alkassis², Khalid Alkhatib³, Logan Briggs⁴, Alexander P Cole⁵, Adam S Kibel³, Quoc-Dien Trinh⁶

Affiliations

¹ Division of Urological Surgery, Brigham and Women's Hospital, 45 Francis Street, Boston, MA 02115, USA. Electronic address: https://twitter.com/mdlabban.
² Department of Urology, Hôtel Dieu de France, Université Saint Joseph, Alfred Naccache Boulevard, Beirut, Lebanon. Electronic address: https://twitter.com/Mar1K6.
³ Division of Urological Surgery, Brigham and Women's Hospital, 45 Francis Street, Boston, MA 02115, USA.
⁴ Division of Urological Surgery, Brigham and Women's Hospital, 45 Francis Street, Boston, MA 02115, USA. Electronic address: https://twitter.com/LoganGBriggs1.
⁵ Division of Urological Surgery, Brigham and Women's Hospital, 45 Francis Street, Boston, MA 02115, USA. Electronic address: https://twitter.com/Putnam_Cole.
⁶ Division of Urological Surgery, Brigham and Women's Hospital, 45 Francis Street, Boston, MA 02115, USA. Electronic address: [email protected].

PMID: 35428436
DOI: 10.1016/j.ucl.2022.01.001

Abstract

Androgen deprivation therapy, used alone or in combination, inhibits androgen activity either upstream at the level of the pituitary gland or downstream by disrupting the androgenesis pathway in the adrenal or androgen activity in prostate cells. Its appropriate utilization varies depending on disease stage, aggressivity, and resistance. Special consideration should be given to side effects, as it can affect patients' quality of life and their treatment of other conditions.

Keywords: Androgen antagonists; Androgen deprivation therapy; Hormonal adverse effects; Hormone treatment; Prostatic neoplasm.

Publication types

Review

MeSH terms

Androgen Antagonists* / adverse effects
Androgens / therapeutic use
Antineoplastic Agents, Hormonal / therapeutic use
Humans
Male
Prostatic Neoplasms* / drug therapy
Quality of Life

Substances

Androgen Antagonists
Androgens
Antineoplastic Agents, Hormonal