Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS

Clarisse Marotz; Rebecca Molinsky; Cameron Martino; Bruno Bohn; Sumith Roy; Michael Rosenbaum; Moïse Desvarieux; Melana Yuzefpolskaya; Bruce J Paster; David R Jacobs; Paolo C Colombo; Panos N Papapanou; Rob Knight; Ryan T Demmer

doi:10.1038/s41522-022-00289-w

Early microbial markers of periodontal and cardiometabolic diseases in ORIGINS

NPJ Biofilms Microbiomes. 2022 Apr 20;8(1):30. doi: 10.1038/s41522-022-00289-w.

Authors

Clarisse Marotz¹, Rebecca Molinsky², Cameron Martino^{1

3

4}, Bruno Bohn², Sumith Roy⁵, Michael Rosenbaum⁶, Moïse Desvarieux⁵, Melana Yuzefpolskaya⁷, Bruce J Paster^{8

9}, David R Jacobs², Paolo C Colombo⁷, Panos N Papapanou¹⁰, Rob Knight^{1

4

11}, Ryan T Demmer^{12

13}

Affiliations

¹ Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
² Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
³ Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA.
⁴ Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.
⁵ Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
⁶ Division of Molecular Genetics, Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA.
⁷ Division of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York, NY, USA.
⁸ Department of Molecular Genetics, The Forsyth Institute, Cambridge, MA, USA.
⁹ Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
¹⁰ Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, Columbia University, New York, NY, USA.
¹¹ Department of Computer Science & Engineering, University of California, San Diego, La Jolla, CA, USA.
¹² Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA. [email protected].
¹³ Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. [email protected].

Abstract

Periodontitis affects up to 50% of individuals worldwide, and 8.5% are diagnosed with diabetes. The high-comorbidity rate of these diseases may suggest, at least in part, a shared etiology and pathophysiology. Changes in oral microbial communities have been documented in the context of severe periodontitis and diabetes, both independently and together. However, much less is known about the early oral microbial markers of these diseases. We used a subset of the ORIGINS project dataset, which collected detailed periodontal and cardiometabolic information from 787 healthy individuals, to identify early microbial markers of periodontitis and its association with markers of cardiometabolic health. Using state-of-the-art compositional data analysis tools, we identified the log-ratio of Treponema to Corynebacterium bacteria to be a novel Microbial Indicator of Periodontitis (MIP), and found that this MIP correlates with poor periodontal health and cardiometabolic markers early in disease pathogenesis in both subgingival plaque and saliva.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Bacteria / genetics
Cardiovascular Diseases*
Humans
Microbiota*
Periodontitis* / microbiology
Saliva / microbiology

Abstract

Publication types

MeSH terms

Grants and funding