Homecoming of the estranged GluD channels

Jamie A Abbott; Gabriela K Popescu

doi:10.1016/j.tins.2022.04.001

Homecoming of the estranged GluD channels

Trends Neurosci. 2022 Jul;45(7):499-501. doi: 10.1016/j.tins.2022.04.001. Epub 2022 Apr 27.

Authors

Jamie A Abbott¹, Gabriela K Popescu²

Affiliations

¹ Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, 955 Main Street, Buffalo, NY 14203, USA.
² Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, 955 Main Street, Buffalo, NY 14203, USA. Electronic address: [email protected].

Abstract

A recent paper by Carrillo and colleagues demonstrates that GluD proteins form bona fide ligand-gated ion channels when their intrinsic flexibility is constrained by interactions with protein partners. Therefore, Delta receptors resemble all other members of the ionotropic glutamate receptor family not only by sequence and structural homology, but also by functional dynamics.

Keywords: FRET; delta receptors; ionotropic glutamate receptors; ligand-gated ion channels; synaptic transmission.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Humans
Ion Channel Gating*
Proteins
Receptors, Ionotropic Glutamate* / chemistry

Substances

Proteins
Receptors, Ionotropic Glutamate

Abstract

Publication types

MeSH terms

Substances

Grants and funding