Natural terpenoids with anti-inflammatory activities: Potential leads for anti-inflammatory drug discovery

Jiamin Ge; Zhen Liu; Zhichao Zhong; Liwei Wang; Xiaotao Zhuo; Junjie Li; Xiaoying Jiang; Xiang-Yang Ye; Tian Xie; Renren Bai

doi:10.1016/j.bioorg.2022.105817

Natural terpenoids with anti-inflammatory activities: Potential leads for anti-inflammatory drug discovery

Bioorg Chem. 2022 Jul:124:105817. doi: 10.1016/j.bioorg.2022.105817. Epub 2022 Apr 25.

Authors

Jiamin Ge¹, Zhen Liu², Zhichao Zhong¹, Liwei Wang², Xiaotao Zhuo², Junjie Li², Xiaoying Jiang³, Xiang-Yang Ye⁴, Tian Xie⁵, Renren Bai⁶

Affiliations

¹ College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China; School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine, Engineering Laboratory of Development and Application of Traditional Chinese Medicine, Collaborative Innovation Center of Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China.
² School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine, Engineering Laboratory of Development and Application of Traditional Chinese Medicine, Collaborative Innovation Center of Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China.
³ College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou 311121, PR China.
⁴ School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine, Engineering Laboratory of Development and Application of Traditional Chinese Medicine, Collaborative Innovation Center of Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China. Electronic address: [email protected].
⁵ School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine, Engineering Laboratory of Development and Application of Traditional Chinese Medicine, Collaborative Innovation Center of Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China. Electronic address: [email protected].
⁶ School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine, Engineering Laboratory of Development and Application of Traditional Chinese Medicine, Collaborative Innovation Center of Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China. Electronic address: [email protected].

PMID: 35490583
DOI: 10.1016/j.bioorg.2022.105817

Abstract

Natural products are mainly secondary metabolites produced by plants, microorganisms, and animals, which are still abundant in modern drug discovery. Terpenoids are the most diverse group of natural products, attracting extensive attention owing to their various biological activities. This manuscript reviewed the chemical structures, anti-inflammatory activities, and mechanisms of action of 281 terpenoid natural products reported from 2010 to the present. Their biological targets and both in vitro and in vivo screening models were also surveyed and statistically summarized. This review will provide potential anti-inflammatory lead compounds and helpful information to researchers engaged in natural products and anti-inflammatory drug discovery.

Keywords: Anti-inflammatory activities; Drug discovery; Natural products; Targets; Terpenoids.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents / therapeutic use
Biological Products* / chemistry
Drug Discovery
Terpenes* / chemistry

Substances

Anti-Inflammatory Agents
Biological Products
Terpenes