Extracellular vesicle-induced cyclic AMP signaling

Cell Signal. 2022 Jul:95:110348. doi: 10.1016/j.cellsig.2022.110348. Epub 2022 Apr 30.

Abstract

Second messenger signaling is required for cellular processes. We previously reported that extracellular vesicles (EVs) from stimulated cultured endothelial cells contain the biochemical second messenger, cAMP. In the current study, we sought to determine whether cAMP-enriched EVs induce second messenger signaling pathways in naïve recipient cells. Our results indicate that cAMP-enriched EVs increase cAMP content sufficient to stimulate PKA activity. The implications of our work are that EVs represent a novel intercellular mechanism for second messenger, specifically cAMP, signaling.

Keywords: Cyclic adenosine monophosphate; Extracellular vesicles; Microvesicle; Second messenger.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cells, Cultured
  • Cyclic AMP* / metabolism
  • Endothelial Cells / metabolism
  • Extracellular Vesicles* / metabolism
  • Second Messenger Systems
  • Signal Transduction

Substances

  • Cyclic AMP