PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms

Xu Chen; Riccardo Calandrelli; John Girardini; Zhangming Yan; Zhiqun Tan; Xiangmin Xu; Annie Hiniker; Sheng Zhong

doi:10.1016/j.cmet.2022.02.008

PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms

Cell Metab. 2022 May 3;34(5):651-653. doi: 10.1016/j.cmet.2022.02.008.

Authors

Xu Chen¹, Riccardo Calandrelli², John Girardini³, Zhangming Yan², Zhiqun Tan⁴, Xiangmin Xu⁵, Annie Hiniker⁶, Sheng Zhong⁷

Affiliations

¹ Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. Electronic address: [email protected].
² Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
³ Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
⁴ Institute for Memory Impairments and Neurological Disorders, University of California, Irvine School of Medicine, Irvine, CA, USA; Department of Anatomy and Neurobiology, University of California, Irvine School of Medicine, Irvine, CA, USA.
⁵ Department of Anatomy and Neurobiology, University of California, Irvine School of Medicine, Irvine, CA, USA.
⁶ Department of Pathology, University of California, San Diego, La Jolla, CA, USA.
⁷ Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA; Genemo, Inc., San Diego, CA, USA. Electronic address: [email protected].

Abstract

Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease* / metabolism
Animals
Brain / metabolism
Cell Line, Tumor
Mice
Phosphoglycerate Dehydrogenase* / genetics
Phosphoglycerate Dehydrogenase* / metabolism
RNA, Messenger / genetics
RNA, Messenger / metabolism
Serine / metabolism

Substances

RNA, Messenger
Serine
Phosphoglycerate Dehydrogenase

Abstract

Publication types

MeSH terms

Substances

Grants and funding