Left anterior descending artery aneurysm in a young patient with familial retinal arterial macroaneurysm: A case report

Husaam Haidar; Ahmed F Alohali; Abdulaziz S Albaradai; Mohammed Alreshidan; Mohmmed A Algamdi

doi:10.1016/j.ajoc.2022.101548

Left anterior descending artery aneurysm in a young patient with familial retinal arterial macroaneurysm: A case report

Am J Ophthalmol Case Rep. 2022 Apr 29:26:101548. doi: 10.1016/j.ajoc.2022.101548. eCollection 2022 Jun.

Authors

Husaam Haidar¹, Ahmed F Alohali², Abdulaziz S Albaradai³, Mohammed Alreshidan³, Mohmmed A Algamdi^{2

4}

Affiliations

¹ Intensive Care Department, Aseer Central Hospital, Abha, Saudi Arabia.
² Critical Care Services Administration, King Fahad Medical City, Riyadh, Saudi Arabia.
³ Adult Cardiovascular Surgery, King Fahad Medical City, Riyadh, Saudi Arabia.
⁴ Pulmonary Section, Department of Medicine, King Fahad Medical City, Riyadh, Saudi Arabia.

Abstract

Purpose: Familial retinal arterial macroaneurysm (FRAM) is a rare genetic disorder caused by a gene mutation in the insulin-like growth factor binding protein 7 (IGFBP7).

Observations: We report a 30-year-old male with FRAM and IGFBP7 gene mutation who presented with an acute coronary syndrome (ACS). Invasive coronary angiography revealed a large aneurysm at the proximal part of the left anterior descending (LAD) artery.

Conclusions and importance: Few cases with systemic vascular involvement in patients with FRAM have been described before; however, our case represents the first documentation of a LAD artery aneurysm in a patient with FRAM and IGFBP7 gene mutation.

Publication types

Case Reports