Insights into how SARS-CoV2 infection induces cytokine storms

Kevin John Selva; Amy W Chung

doi:10.1016/j.it.2022.04.007

Insights into how SARS-CoV2 infection induces cytokine storms

Trends Immunol. 2022 Jun;43(6):417-419. doi: 10.1016/j.it.2022.04.007. Epub 2022 May 7.

Authors

Kevin John Selva¹, Amy W Chung²

Affiliations

¹ Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
² Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia. Electronic address: [email protected].

Abstract

Severe coronavirus disease 2019 (COVID-19) has been associated with cytokine storms and hyperinflammation. In a recent study, Junqueira et al. provide evidence that antibody-mediated uptake of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus by monocytes and macrophages may contribute to this inflammation by activating inflammasomes which trigger pyroptosis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

COVID-19*
Cytokine Release Syndrome*
Humans
Inflammasomes
RNA, Viral
SARS-CoV-2

Substances

Inflammasomes
RNA, Viral