Transition metal/Brønsted acid cooperative catalysis enabled facile synthesis of 8-hydroxyquinolines through one-pot reactions of ortho-aminophenol, aldehydes and alkynes

Shuyan Yu; Jingxin Wu; Hongbing Lan; Hanwen Xu; Xiaofei Shi; Xuewen Zhu; Zhigang Yin

doi:10.1039/c8ra07212d

Transition metal/Brønsted acid cooperative catalysis enabled facile synthesis of 8-hydroxyquinolines through one-pot reactions of ortho-aminophenol, aldehydes and alkynes

RSC Adv. 2018 Oct 3;8(59):33968-33971. doi: 10.1039/c8ra07212d. eCollection 2018 Sep 28.

Authors

Shuyan Yu¹, Jingxin Wu¹, Hongbing Lan¹, Hanwen Xu¹, Xiaofei Shi¹, Xuewen Zhu¹, Zhigang Yin¹

Affiliation

¹ Material and Chemical Engineering College, Zhengzhou University of Light Industry Zhengzhou 450002 Henan People's Republic of China.

Abstract

A convenient and straightforward three-component one-pot strategy has been developed for the synthesis of 8-hydroxyquinoline derivatives. Under the cooperative catalysis of silver(i) triflate and trifluoroacetic acid, ortho-aminophenol reacted with a range of aldehydes and alkynes under mild reactions, affording the corresponding 8-hydroxyquinoline derivatives with good to excellent yields. These transformations exhibited exceptional substrate generality and functional group compatibility.