Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain

Life Sci. 2022 Aug 15:303:120601. doi: 10.1016/j.lfs.2022.120601. Epub 2022 May 10.

Abstract

The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.

Keywords: Circadian; Gut-Brain Axis; Metabolism; Microbiome; Neurometabolism; Systems biology.

MeSH terms

  • Animals
  • Anti-Bacterial Agents* / pharmacology
  • Brain / metabolism
  • Gastrointestinal Microbiome*
  • Mammals
  • Mice
  • Suprachiasmatic Nucleus

Substances

  • Anti-Bacterial Agents