Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling

Beatrice Vignoli; Marco Canossa

doi:10.3390/cells11091501

Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling

Cells. 2022 Apr 29;11(9):1501. doi: 10.3390/cells11091501.

Authors

Beatrice Vignoli¹, Marco Canossa²

Affiliations

¹ Department of Physics, University of Trento, 38123 Povo (TN), Italy.
² Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Povo (TN), Italy.

Abstract

Neurons release and respond to brain-derived neurotrophic factor (BDNF) with bursts of brain activity. BDNF action is known to extend to peri-synaptic astrocytes, contributing to synaptic strengthening. This implies that astrocytes have a set of dynamic responses, some of which might be secondary to activation of the tropomyosin tyrosine kinase B (TrkB) receptor. Here, we assessed the contribution of BDNF to long-term synaptic potentiation (LTP), by specifically deleting TrkB in cortical astrocytes. TrkB deletion had no effect on LTP induction, stabilization and maintenance, indicating that TrkB signaling in astrocytes is extraneous to transducing BDNF activity for synaptic strengthening.

Keywords: astrocyte microdomains; neuron–astrocyte communication; synaptic strengthening.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Astrocytes / metabolism
Brain-Derived Neurotrophic Factor* / metabolism
Perirhinal Cortex* / metabolism
Protein-Tyrosine Kinases / metabolism
Receptor, trkB / metabolism

Substances

Brain-Derived Neurotrophic Factor
Protein-Tyrosine Kinases
Receptor, trkB

Grants and funding

This research was funded by Progetti di Ricerca di Rilevanza Nazionale (PRIN)-Bando 2017, grant number 2017HPTFFCPRIN; European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program, grant number 788793-BACKUP.