Delayed drug hypersensitivity reaction to secukinumab in a patient with hidradenitis suppurativa

BMJ Case Rep. 2022 May 17;15(5):e249684. doi: 10.1136/bcr-2022-249684.

Abstract

A woman in her 30s presented to the dermatology clinic with widespread, pruritic, red papules and plaques involving the ears, trunk and extremities. The rash developed a few days after receiving her second injection of secukinumab, which was initiated for recalcitrant Hurley stage III hidradenitis suppurativa. Investigations revealed a psoriasiform drug hypersensitivity reaction secondary to secukinumab. In this report, we describe the clinical course, histopathological correlation and treatment of this rarely documented reaction.

Keywords: Dermatology; Hidradenitis suppurativa; Skin; Unwanted effects / adverse reactions.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal, Humanized / adverse effects
  • Drug Hypersensitivity* / etiology
  • Female
  • Hidradenitis Suppurativa* / drug therapy
  • Humans
  • Psoriasis*

Substances

  • Antibodies, Monoclonal, Humanized
  • secukinumab