Occupational Lung Disease Caused by Exposure to Polytetrafluoroethylene

Intern Med. 2022 Dec 15;61(24):3713-3717. doi: 10.2169/internalmedicine.9008-21. Epub 2022 May 21.

Abstract

We herein report a 45-year-old-man with multiple foreign body granulomas in the lungs caused by polytetrafluoroethylene (PTFE). A mass in the right lower lobe of the lung and bilateral centrilobular lung nodules were found unexpectedly during the patient's visit to a hospital for a respiratory infection. The patient's occupation for 26 years involved spraying PTFE. A lung biopsy using bronchoscopy revealed granulomatous lesions and giant cells. The presence of fluorine in the granulomatous lesions was confirmed using an electron probe microanalyzer with wavelength dispersive spectrometer. Fluorine is a component of PTFE and is not found in normal lung tissue.

Keywords: electron probe microanalyzer with wavelength dispersive spectrometer; granuloma; polytetrafluoroethylene.

MeSH terms

  • Fluorine
  • Granuloma / pathology
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Diseases* / etiology
  • Lung Diseases* / pathology
  • Middle Aged
  • Occupational Diseases* / complications
  • Polytetrafluoroethylene / adverse effects

Substances

  • Polytetrafluoroethylene
  • Fluorine