Higher In Vivo Fecal Concentrations of Clostridioides difficile Toxins A and B in Patients With North American Pulsed-Field Gel Electrophoresis Type 1/Ribotype 027 Strain Infection

Clin Infect Dis. 2022 Nov 30;75(11):2019-2022. doi: 10.1093/cid/ciac406.

Abstract

Ultrasensitive, quantitative Clostridioides difficile stool toxin measurement demonstrated significantly higher concentrations of toxins A and B in patients infected with the North American pulsed-field gel electrophoresis type 1/ribotype 027 (NAP-1/027) strain compared with other strains, providing in vivo confirmation of the in vitro association between NAP-1/027 and elevated toxin production.

Keywords: Clostridioides difficile; NAP-1/027 strain; clinical outcomes; toxin concentration.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antibodies, Bacterial
  • Bacterial Proteins / analysis
  • Bacterial Proteins / genetics
  • Bacterial Toxins* / analysis
  • Bacterial Toxins* / genetics
  • Clostridioides difficile* / genetics
  • Clostridium Infections*
  • Electrophoresis, Gel, Pulsed-Field
  • Enterotoxins / analysis
  • Enterotoxins / genetics
  • Feces / chemistry
  • Humans
  • North America
  • Ribotyping

Substances

  • Enterotoxins
  • Bacterial Toxins
  • Antibodies, Bacterial
  • Bacterial Proteins