Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease

Anna C Riddell; Beatrix Kele; Kathryn Harris; Jon Bible; Maurice Murphy; Subathira Dakshina; Nathaniel Storey; Dola Owoyemi; Corinna Pade; Joseph M Gibbons; David Harrington; Eliza Alexander; Áine McKnight; Teresa Cutino-Moguel

doi:10.1093/cid/ciac409

Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease

Clin Infect Dis. 2022 Nov 30;75(11):2016-2018. doi: 10.1093/cid/ciac409.

Affiliations

¹ Virology Department, Division of Infection, Barts Health NHS Trust, London, United Kingdom.
² Department of Infection and Immunity, Barts Health NHS Trust, London, United Kingdom.
³ Microbiology, Virology, and Infection Prevention and Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.
⁴ Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Abstract

The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is of public health concern in case of vaccine escape. Described are 3 patients with advanced human immunodeficiency virus (HIV)-1 and chronic SARS-CoV-2 infection in whom there is evidence of selection and persistence of novel mutations that are associated with increased transmissibility and immune escape.

Keywords: Alpha variant; B.1.1.7; HIV-1 infection; SARS CoV-2; immunocompromised.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

COVID-19*
Graft vs Host Disease*
HIV-1* / genetics
Humans
SARS-CoV-2 / genetics

Supplementary concepts

SARS-CoV-2 variants